Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 11/20 | 0.33 |
| ▸ | FLT1 | P17948 | 10/20 | 0.33 |
| ▸ | SCN4A | P35499 | 3/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | LTA4H | P09960 | 1/20 | 0.31 |
| ▸ | KMO | O15229 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1533910 | 0.82 | KDR (0.36) | KDRFLT1LTA4HKMO | |
| SCHEMBL30807496 | 0.77 | SCN4A (0.30) | SCN4ASCN9A | |
| SCHEMBL6097927 | 0.74 | MAP4K4 (0.36) | KDRSCN4ASCN9APARP1 | |
| SCHEMBL18986536 | 0.74 | MAP4K4 (0.39) | SCN4ASCN9APARP1 | |
| SCHEMBL29813255 | 0.70 | GABRG2 (0.33) | PARP1 | |
| SCHEMBL790464 | 0.69 | SCN4A (0.31) | SCN4ASCN9A | |
| SCHEMBL7519926 | 0.67 | — | — | |
| SCHEMBL14661735 | 0.67 | PARP1 (0.41) | PARP1 | |
| SCHEMBL27564943 | 0.67 | — | — | |
| SCHEMBL1120305 | 0.65 | MAOA (0.56) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0245637-B1 | 4,5,6,7-Tetrahydro-1H-imidazo[4,5-c]pyridine derivatives and analogs having antihypertensive activity | WARNER-LAMBERT COMPANY (US) | 1991-10-16 | — | — | EP | disclosed |
| US-4816463-A | HYPERTENSION | WARNER-LAMBERT COMPANY (US) | 1989-03-28 | — | — | US | disclosed |
| US-4812462-A | 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid analogs having antihypertensive activity | WARNER-LAMBERT COMPANY (US) | 1989-03-14 | — | — | US | disclosed |
| EP-0245637-A1 | 4,5,6,7-Tetrahydro-1H-imidazo[4,5-c]pyridine derivatives and analogs having antihypertensive activity | WARNER-LAMBERT COMPANY (US) | 1987-11-19 | — | — | EP | disclosed |