Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 16/20 | 0.45 |
| ▸ | GABRG2 | P18507 | 16/20 | 0.45 |
| ▸ | GABRB3 | P28472 | 16/20 | 0.45 |
| ▸ | GABRA5 | P31644 | 16/20 | 0.45 |
| ▸ | GABRA3 | P34903 | 16/20 | 0.45 |
| ▸ | GABRA2 | P47869 | 16/20 | 0.45 |
| ▸ | GABRA6 | Q16445 | 14/20 | 0.45 |
| ▸ | GABRA4 | P48169 | 13/20 | 0.45 |
| ▸ | GABRP | O00591 | 12/20 | 0.44 |
| ▸ | GABRD | O14764 | 12/20 | 0.44 |
| ▸ | GABRB1 | P18505 | 12/20 | 0.44 |
| ▸ | GABRB2 | P47870 | 12/20 | 0.44 |
| ▸ | GABRE | P78334 | 12/20 | 0.44 |
| ▸ | GABRG1 | Q8N1C3 | 12/20 | 0.44 |
| ▸ | GABRG3 | Q99928 | 12/20 | 0.44 |
| ▸ | GABRQ | Q9UN88 | 12/20 | 0.44 |
| ▸ | UBE2N | P61088 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9838980 | 0.89 | GABRA1 (0.46) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL9839951 | 0.88 | GABRA1 (0.46) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL9840019 | 0.86 | GABRA1 (0.48) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL9839859 | 0.85 | GABRA1 (0.45) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL9838891 | 0.85 | GABRA1 (0.51) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL9839113 | 0.83 | GABRA1 (0.58) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL9839990 | 0.80 | GABRA1 (0.40) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL9537464 | 0.77 | GABRP (0.64) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL10634255 | 0.76 | GABRA1 (0.67) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL9840114 | 0.75 | GABRA1 (0.46) | GABRA1GABRG2GABRB3GABRA5GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0222693-B1 | 3-OXADIAZOLYL AND 3-CARBOXYLIC-ACID BETA-CARBOLINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1991-04-17 | — | — | EP | disclosed |