Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | HSPA5 | P11021 | 6/20 | 0.47 |
| ▸ | HSPA9 | P38646 | 3/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HSPA2 | P54652 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | FFAR2 | O15552 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HSPA8 | P11142 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10946561 | 0.91 | NPC1 (0.44) | HTTTP53L3MBTL1HSPA5HSPA9 | |
| SCHEMBL10660806 | 0.88 | RECQL (0.46) | HTTTP53L3MBTL1HSPA5HSPA9 | |
| SCHEMBL10665055 | 0.86 | CYP1A2 (0.46) | HTTTP53L3MBTL1HSPA5HSPA9 | |
| SCHEMBL10660923 | 0.86 | NPC1 (0.44) | HTTTP53L3MBTL1HSPA5HSPA9 | |
| SCHEMBL10945760 | 0.85 | NPC1 (0.43) | HTTTP53L3MBTL1HSPA5HSPA9 | |
| SCHEMBL9839297 | 0.83 | TLR7 (0.46) | NPSR1TSHRFFAR2KDM4EHSD17B10 | |
| SCHEMBL10665884 | 0.83 | SMN1; SMN2 (0.46) | HTTTP53L3MBTL1HSPA5HSPA9 | |
| SCHEMBL10665753 | 0.80 | HTT (0.49) | HTTTP53L3MBTL1HSPA5HSPA9 | |
| SCHEMBL10665904 | 0.77 | HSPA5 (0.60) | HTTTP53L3MBTL1HSPA5HSPA9 | |
| SCHEMBL10660312 | 0.75 | TLR7 (0.47) | NPSR1LMNATSHRFFAR2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4988708-A | 3-Carbamoyl-4-hydroxy-2-carboxylmethyl quinoline analgesics, antiinflammatory agents | ROUSSEL UCLAF (FR) | 1991-01-29 | — | — | US | disclosed |
| US-4845105-A | 4-OH-quinoline carboxylic acid amides having analgesic and anti-inflammatory activity | ROUSSEL UCLAF (FR) | 1989-07-04 | — | — | US | disclosed |
| US-4735951-A | Novel 4-hydroxy-3-quinoline-carboxylates having analgesic and anti-inflammatory activity | ROUSSEL UCLAF (FR) | 1988-04-05 | — | — | US | disclosed |