Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 5/20 | 0.42 |
| ▸ | RAB9A | P51151 | 5/20 | 0.42 |
| ▸ | HSPA5 | P11021 | 2/20 | 0.42 |
| ▸ | HSPA9 | P38646 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10945760 | 0.88 | NPC1 (0.43) | SMN1; SMN2TP53HTTL3MBTL1NPC1 | |
| SCHEMBL10946561 | 0.86 | NPC1 (0.44) | SMN1; SMN2TP53HTTL3MBTL1NPC1 | |
| SCHEMBL10660806 | 0.84 | RECQL (0.46) | SMN1; SMN2TP53HTTL3MBTL1NPC1 | |
| SCHEMBL9839295 | 0.83 | HTT (0.48) | SMN1; SMN2TP53HTTL3MBTL1NPC1 | |
| SCHEMBL10665055 | 0.82 | CYP1A2 (0.46) | SMN1; SMN2TP53HTTL3MBTL1NPC1 | |
| SCHEMBL10660923 | 0.80 | NPC1 (0.44) | SMN1; SMN2TP53HTTL3MBTL1NPC1 | |
| SCHEMBL10665753 | 0.73 | HTT (0.49) | SMN1; SMN2TP53HTTL3MBTL1NPC1 | |
| SCHEMBL10351392 | 0.70 | NPC1 (0.48) | SMN1; SMN2TP53HTTL3MBTL1NPC1 | |
| SCHEMBL10665904 | 0.70 | HSPA5 (0.60) | SMN1; SMN2TP53HTTL3MBTL1NPC1 | |
| SCHEMBL10660312 | 0.69 | TLR7 (0.47) | NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4736033-A | Certain 1,3-dihydro-1-[heterocyclic)imino]-furo-[3,4-b]quinoline 9-ol compounds having analgesic and anti-inflammatory activity | ROUSSEL UCLAF (FR) | 1988-04-05 | — | — | US | disclosed |
| US-4596875-A | Reacting benzoxazole compound with amide to decyclize, cyclizing to form quinoline derivative | ROUSSEL UCLAF (FR) | 1986-06-24 | — | — | US | disclosed |
| US-4486438-A | 4-Hydroxy-3-quinoline-carboxylic acid derivatives | ROUSSEL UCLAF (FR) | 1984-12-04 | — | — | US | disclosed |