Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | PNMT | P11086 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4880319 | 0.77 | NPC1 (0.39) | NPC1RAB9APNMT | |
| Hydrochloric Acid SCHEMBL8604647 | 0.74 | PNMT (0.44) | NPC1RAB9APNMTBCHELMNA | |
| Hydrochloric Acid SCHEMBL5856595 | 0.73 | PNMT (0.37) | NPC1RAB9APNMT | |
| Hydrochloric Acid SCHEMBL6836898 | 0.72 | NPC1 (0.36) | NPC1RAB9APNMTBCHEACHE | |
| Hydrochloric Acid SCHEMBL5853341 | 0.71 | HTT (0.43) | NPC1RAB9ALMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL7628022 | 0.70 | PNMT (0.42) | NPC1RAB9APNMTBCHELMNA | |
| Hydrochloric Acid SCHEMBL6836890 | 0.69 | PNMT (0.38) | NPC1RAB9APNMTBCHEACHE | |
| Hydrochloric Acid SCHEMBL216029 | 0.68 | PNMT (0.35) | NPC1RAB9APNMT | |
| SCHEMBL9221121 | 0.66 | PNMT (0.53) | PNMTLMNAALDH1A1 | |
| SCHEMBL6836896 | 0.66 | NPC1 (0.36) | NPC1RAB9APNMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991004257-A1 | MONOCYCLOPENTADIENYL TRANSITION METAL OLEFIN POLYMERIZATION CATALYSTS | EXXON CHEMICAL PATENTS INC. (US) | 1991-04-04 | — | — | WO | disclosed |