Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 2/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.45 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.45 |
| ▸ | TNKS | O95271 | 1/20 | 0.44 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.44 |
| ▸ | RARB | P10826 | 2/20 | 0.43 |
| ▸ | RARG | P13631 | 2/20 | 0.43 |
| ▸ | ADH5 | P11766 | 1/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9840136 | 0.85 | ROCK1 (0.49) | CRBNROCK1BRD4CREBBPROCK2 | |
| SCHEMBL9313154 | 0.84 | TNKS (0.50) | TNKSTNKS2KMT2AHTTL3MBTL1 | |
| SCHEMBL9312256 | 0.81 | RARB (0.51) | TNKSTNKS2KMT2ACYP3A4RARB | |
| SCHEMBL9314264 | 0.81 | MEN1 (0.53) | TNKSTNKS2KMT2AMAPTCYP3A4 | |
| SCHEMBL9866488 | 0.80 | TNKS (0.52) | TNKSTNKS2KMT2ACYP3A4RARB | |
| SCHEMBL9865756 | 0.79 | MEN1 (0.55) | TNKSTNKS2KMT2AMAPTCYP3A4 | |
| SCHEMBL9314211 | 0.78 | MEN1 (0.50) | TNKSTNKS2KMT2AMAPTCYP3A4 | |
| SCHEMBL10587722 | 0.78 | KMT2A (0.56) | KMT2AMAPTCYP3A4RARBRARG | |
| SCHEMBL9379480 | 0.78 | BACE1 (0.52) | TNKSTNKS2KMT2AMAPTL3MBTL1 | |
| SCHEMBL9313806 | 0.77 | ADORA3 (0.48) | ROCK2TNKSTNKS2KMT2ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4985448-A | Ureidoindoles, pharmaceutical compositions and methods for erythrocyte and thrombocyte aggregation inhibition | BOEHRINGER MANNHEIM GMBH (DE) | 1991-01-15 | — | — | US | disclosed |
| EP-0327986-A2 | Medicaments containing lactams, substituted lactams and process for their preparation | Roche Diagnostics GmbH (DE) | 1989-08-16 | — | — | EP | disclosed |