Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.50 |
| ▸ | NPC1 | O15118 | 6/20 | 0.50 |
| ▸ | RAB9A | P51151 | 6/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.50 |
| ▸ | RELA | Q04206 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.45 |
| ▸ | MEN1 | O00255 | 7/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | NSD2 | O96028 | 1/20 | 0.40 |
| ▸ | ALPL | P05186 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13268068 | 0.82 | MAPT (0.56) | MAPTNPC1RAB9ALMNANFKB1 | |
| SCHEMBL19185513 | 0.74 | MAPT (0.46) | MAPTNPC1RAB9ALMNANFKB1 | |
| Lithium Ion SCHEMBL7175365 | 0.71 | MAPT (0.45) | MAPTNPC1RAB9ALMNANFKB1 | |
| SCHEMBL4431855 | 0.70 | WDR5 (0.44) | MAPTNPC1RAB9ALMNASMN1; SMN2 | |
| SCHEMBL8883226 | 0.69 | LMNA (0.46) | NPC1RAB9ALMNASMN1; SMN2KMT2A | |
| SCHEMBL9747245 | 0.67 | POLB (0.40) | MAPTNPC1RAB9ALMNANFKB1 | |
| SCHEMBL9749415 | 0.65 | MAPK14 (0.52) | MAPTNPC1RAB9ALMNANFKB1 | |
| SCHEMBL8937107 | 0.64 | KCNH2 (0.52) | MAPTNPC1RAB9ALMNATP53 | |
| SCHEMBL8937080 | 0.64 | KCNH2 (0.52) | MAPTNPC1RAB9ALMNATP53 | |
| SCHEMBL18660408 | 0.64 | TP53 (0.42) | MAPTSMN1; SMN2TP53GAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5008390-A | Compounds for preparing 6-phenyl-2,3-dihydroimidazo[2,1-b]-thiazoles and corresponding thiazines | SMITHKLINE BECKMAN CORPORATION (US) | 1991-04-16 | — | — | US | disclosed |
| US-4803279-A | 1.4-dihydro-4-pyridyl-substituted imidazo (2,1-b) thiazoles and the corresponding thiazines. | SMITHKLINE BECKMAN CORPORATION (US) | 1989-02-07 | — | — | US | disclosed |
| EP-0203787-A2 | Process for preparing pyridyl-substituted imidazo[2,1-b]thiazoles and thiazines | SMITHKLINE BEECHAM CORPORATION (US) | 1986-12-03 | — | — | EP | disclosed |