SCHEMBL9842404

SCHEMBL9842404

C#Cc1cccc(F)c1C=O

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.40
KMT2A Q03164 2/20 0.40
MEN1 O00255 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
ERN1 O75460 1/20 0.38
NFE2L2 Q16236 2/20 0.35
IKBKB O14920 1/20 0.34
LMNA P02545 2/20 0.32
KDM4E B2RXH2 1/20 0.32
HPGD P15428 1/20 0.32
ALOX12 P18054 1/20 0.32
ATM Q13315 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
ABCG2 Q9UNQ0 1/20 0.32
CES2 O00748 1/20 0.31
CES1 P23141 1/20 0.31
MDM4 O15151 1/20 0.31
MAPT P10636 1/20 0.31
MDM2 Q00987 1/20 0.31
GAA P10253 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6516779 0.85 MEN1 (0.48) ALDH1A1KMT2AMEN1TDP1LMNA
SCHEMBL29955549 0.80 ERN1 (0.38) ALDH1A1KMT2AMEN1TDP1ERN1
SCHEMBL7530450 0.80 ERN1 (0.38) ALDH1A1KMT2AMEN1TDP1ERN1
SCHEMBL95708 0.78 ERN1 (0.50) ALDH1A1KMT2AMEN1TDP1ERN1
SCHEMBL4720705 0.77 ERN1 (0.36) ALDH1A1KMT2AMEN1TDP1ERN1
SCHEMBL22721472 0.75 ABCG2 (0.43) ALDH1A1KMT2ATDP1NFE2L2LMNA
SCHEMBL24650244 0.74 ERN1 (0.34) ALDH1A1KMT2AMEN1TDP1ERN1
SCHEMBL3056776 0.73 CREBBP (0.35) ALDH1A1KMT2AMEN1TDP1ERN1
SCHEMBL154430 0.72 ALDH1A1 (0.70) ALDH1A1KMT2AMEN1TDP1LMNA
SCHEMBL32666059 0.72 ERN1 (0.42) ALDH1A1KMT2AMEN1TDP1ERN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4127157-B1 MODIFIED DIPEPTIDE CLEAVASES, USES THEREOF AND RELATED KITS ENCODIA INC (US) 2026-02-11 EP claimed
US-20240011009-A1 MODIFIED DIPEPTIDE CLEAVASES, USES THEREOF AND RELATED KITS Encodia, Inc. (US) 2024-01-11 US claimed
EP-4127157-A1 MODIFIED DIPEPTIDE CLEAVASES, USES THEREOF AND RELATED KITS Encodia, Inc. (US) 2023-02-08 EP claimed
WO-2022072560-A1 POLYPEPTIDE TERMINAL BINDERS AND USES THEREOF Encodia, Inc. (US) 2022-04-07 WO claimed
WO-2021194908-A1 MODIFIED DIPEPTIDE CLEAVASES, USES THEREOF AND RELATED KITS Encodia, Inc. (US) 2021-09-30 WO claimed
EP-4127157-B1 MODIFIED DIPEPTIDE CLEAVASES, USES THEREOF AND RELATED KITS ENCODIA INC (US) 2026-02-11 EP disclosed
US-20240011009-A1 MODIFIED DIPEPTIDE CLEAVASES, USES THEREOF AND RELATED KITS Encodia, Inc. (US) 2024-01-11 US disclosed
US-11788080-B2 Modified cleavases, uses thereof and related kits Encodia, Inc. (US) 2023-10-17 US disclosed
US-20230257727-A1 MODIFIED CLEAVASES, USES THEREOF AND RELATED KITS Encodia, Inc. (US) 2023-08-17 US disclosed
US-20230220589-A1 POLYPEPTIDE TERMINAL BINDERS AND USES THEREOF Encodia, Inc. (US) 2023-07-13 US disclosed
EP-4127157-A1 MODIFIED DIPEPTIDE CLEAVASES, USES THEREOF AND RELATED KITS Encodia, Inc. (US) 2023-02-08 EP disclosed
US-20230021091-A1 MODIFIED CLEAVASES, USES THEREOF AND RELATED KITS Encodia, Inc. (US) 2023-01-19 US disclosed
US-11427814-B2 Modified cleavases, uses thereof and related kits Encodia, Inc. (US) 2022-08-30 US disclosed
WO-2022072560-A1 POLYPEPTIDE TERMINAL BINDERS AND USES THEREOF Encodia, Inc. (US) 2022-04-07 WO disclosed
WO-2021194908-A1 MODIFIED DIPEPTIDE CLEAVASES, USES THEREOF AND RELATED KITS Encodia, Inc. (US) 2021-09-30 WO disclosed
US-20210214701-A1 MODIFIED CLEAVASES, USES THEREOF AND RELATED KITS Encodia, Inc. (US) 2021-07-15 US disclosed
EP-0461264-A1 ETHYNYLPHENYL DERIVATIVE, PRODUCTION THEREOF, AND REMEDY FOR DISEASES OF CIRCULATORY ORGANS CONTAINING THE SAME AS ACTIVE INGREDIENT KAKEN PHARMACEUTICAL CO., LTD. (JP) 1991-12-18 EP disclosed