Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.66 |
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | HPGD | P15428 | 3/20 | 0.58 |
| ▸ | CA12 | O43570 | 1/20 | 0.55 |
| ▸ | CA1 | P00915 | 1/20 | 0.55 |
| ▸ | CA2 | P00918 | 1/20 | 0.55 |
| ▸ | CA9 | Q16790 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28441128 | 0.86 | MAPT (0.56) | TP53MAPTALDH1A1HPGDCA12 | |
| SCHEMBL19002582 | 0.84 | TP53 (0.68) | TP53MAPTALDH1A1HPGDCA12 | |
| SCHEMBL11161614 | 0.81 | TP53 (0.58) | TP53MAPTALDH1A1HPGDCA12 | |
| SCHEMBL9429120 | 0.81 | TSHR (0.66) | MAPTALDH1A1HPGDCA1CA2 | |
| SCHEMBL8075597 | 0.80 | TP53 (0.72) | TP53MAPTALDH1A1HPGDCA12 | |
| SCHEMBL9842891 | 0.79 | TP53 (0.60) | TP53MAPTALDH1A1HPGDCA12 | |
| SCHEMBL39058 | 0.78 | TP53 (0.75) | TP53MAPTALDH1A1HPGDCA12 | |
| SCHEMBL5542468 | 0.78 | TP53 (0.75) | TP53MAPTALDH1A1HPGDCA12 | |
| SCHEMBL28675540 | 0.78 | TP53 (0.75) | TP53MAPTALDH1A1HPGDCA12 | |
| SCHEMBL8361539 | 0.78 | TP53 (0.75) | TP53MAPTALDH1A1HPGDCA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0440503-A1 | 4-Isoxazolecarboxamide derivatives | SYNTEX (U.S.A.) INC. (US) | 1991-08-07 | — | — | EP | disclosed |