Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 3/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.40 |
| ▸ | KMO | O15229 | 2/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | PRKAB2 | O43741 | 4/20 | 0.36 |
| ▸ | PRKAG1 | P54619 | 4/20 | 0.36 |
| ▸ | PRKAA2 | P54646 | 4/20 | 0.36 |
| ▸ | PRKAA1 | Q13131 | 4/20 | 0.36 |
| ▸ | PRKAG3 | Q9UGI9 | 4/20 | 0.36 |
| ▸ | PRKAG2 | Q9UGJ0 | 4/20 | 0.36 |
| ▸ | PRKAB1 | Q9Y478 | 4/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL981956 | 0.93 | PDE4A (0.38) | PDE4APDE4BPDE4CPDE4DKMO | |
| SCHEMBL981064 | 0.89 | JAK3 (0.46) | JAK2JAK3 | |
| SCHEMBL983691 | 0.89 | KDM4C (0.46) | KMOJAK2JAK3PRKAB2PRKAG1 | |
| SCHEMBL981880 | 0.87 | KMO (0.39) | PDE4APDE4BPDE4CPDE4DKMO | |
| SCHEMBL986385 | 0.87 | BRD4 (0.43) | KMOKDM2BKDM4CBRD4KDM4A | |
| SCHEMBL986109 | 0.85 | HTR4 (0.40) | PDE4APDE4BPDE4CPDE4DBRD4 | |
| SCHEMBL982719 | 0.85 | HTR4 (0.40) | PDE4APDE4BPDE4CPDE4DBRD4 | |
| SCHEMBL981816 | 0.85 | HTR4 (0.50) | PDE4APDE4BPDE4CPDE4DKDM1A | |
| SCHEMBL986107 | 0.85 | BTK (0.43) | PDE4APDE4BPDE4CPDE4DKDM1A | |
| SCHEMBL985165 | 0.85 | BTK (0.43) | PDE4APDE4BPDE4CPDE4DKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8445501-B2 | Substituted 7-carboxamido-pyrrolo[3,2-d]pyrimidines | TAKEDA GMBH (DE) | 2013-05-21 | — | — | US | claimed |
| US-8445501-B2 | Substituted 7-carboxamido-pyrrolo[3,2-d]pyrimidines | TAKEDA GMBH (DE) | 2013-05-21 | — | — | US | disclosed |
| US-20110021479-A1 | PYRROLOPYRIMIDINECARBOXAMIDES | NYCOMED GMBH (DE) | 2011-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110021479-A1 | PYRROLOPYRIMIDINECARBOXAMIDES | PDE5A, PDE3A, PDE2A | PDE4A 6/4885PDE4B 7/4885PDE4C 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.