Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 3/20 | 0.40 |
| ▸ | FAAH | O00519 | 6/20 | 0.39 |
| ▸ | PRCP | P42785 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.38 |
| ▸ | CNR1 | P21554 | 2/20 | 0.37 |
| ▸ | CNR2 | P34972 | 2/20 | 0.37 |
| ▸ | CASP2 | P42575 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.36 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.36 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.36 |
| ▸ | NAAA | Q02083 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL123772 | 0.90 | FAAH (0.47) | EPHX2FAAHPRCPKDM4EDNM1 | |
| Acetic Acid SCHEMBL9844383 | 0.88 | FAAH (0.45) | EPHX2FAAHPRCPKDM4EDNM1 | |
| Phosphoric Acid SCHEMBL9844248 | 0.86 | LPAR1 (0.44) | EPHX2FAAHPRCPKDM4EDNM1 | |
| Lactic Acid SCHEMBL427896 | 0.84 | FAAH (0.41) | EPHX2FAAHPRCPKDM4EDNM1 | |
| Citric Acid SCHEMBL9844147 | 0.78 | PLA2G2C (0.35) | FAAHDNM1GNAI3GNAO1GNAI1 | |
| Citric Acid SCHEMBL8949971 | 0.75 | FAAH (0.58) | EPHX2FAAHKDM4EDNM1CNR1 | |
| Propionic Acid SCHEMBL7185458 | 0.75 | EPHX1 (0.50) | — | |
| Citric Acid SCHEMBL5501214 | 0.74 | FAAH (0.51) | EPHX2FAAHKDM4EDNM1CNR1 | |
| SCHEMBL18381393 | 0.74 | SMN1; SMN2 (0.42) | EPHX2BRD4 | |
| Acetic Acid SCHEMBL5801682 | 0.73 | EPHX1 (0.51) | BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0410659-A2 | Method and composition to impart improved conditioning properties to the hair | HELENE CURTIS, INC. (US) | 1991-01-30 | — | — | EP | claimed |
| US-4976956-A | Water soluble and oil soluble quaternary ammonium compounds and amidoamine | HELENE CURTIS, INC. (US) | 1990-12-11 | — | — | US | claimed |