Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.34 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | GNAI3 | P08754 | 2/20 | 0.34 |
| ▸ | GNAO1 | P09471 | 2/20 | 0.34 |
| ▸ | GNAI1 | P63096 | 2/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.34 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.34 |
| ▸ | PLA2G10 | O15496 | 2/20 | 0.33 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.32 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.32 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.32 |
| ▸ | NAAA | Q02083 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL123771 | 0.89 | MEN1 (0.43) | PLA2G2CFAAHMEN1MAPK1KMT2A | |
| Acetic Acid SCHEMBL9844379 | 0.88 | FAAH (0.40) | PLA2G2CFAAHMEN1MAPK1KMT2A | |
| Lactic Acid SCHEMBL427895 | 0.85 | FAAH (0.42) | PLA2G2CFAAHMEN1MAPK1KMT2A | |
| Phosphoric Acid SCHEMBL9844245 | 0.84 | MEN1 (0.40) | PLA2G2CFAAHMEN1MAPK1KMT2A | |
| Lactic Acid SCHEMBL8519517 | 0.81 | FAAH (0.37) | PLA2G2CFAAHMEN1MAPK1KMT2A | |
| Citric Acid SCHEMBL9844150 | 0.78 | EPHX2 (0.40) | FAAHGNAI3GNAO1GNAI1DNM1 | |
| SCHEMBL17688821 | 0.71 | SLC6A2 (0.37) | MEN1MAPK1KMT2AALDH1A1 | |
| Citric Acid SCHEMBL8330163 | 0.70 | FAAH (0.45) | PLA2G2CFAAHMEN1MAPK1KMT2A | |
| Citric Acid SCHEMBL9189183 | 0.69 | FAAH (0.44) | PLA2G2CFAAHMEN1MAPK1KMT2A | |
| Citric Acid SCHEMBL323488 | 0.69 | FAAH (0.44) | PLA2G2CFAAHMEN1MAPK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0410659-A2 | Method and composition to impart improved conditioning properties to the hair | HELENE CURTIS, INC. (US) | 1991-01-30 | — | — | EP | claimed |
| US-4976956-A | Water soluble and oil soluble quaternary ammonium compounds and amidoamine | HELENE CURTIS, INC. (US) | 1990-12-11 | — | — | US | claimed |