Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.60 |
| ▸ | HTT | P42858 | 3/20 | 0.60 |
| ▸ | HPGD | P15428 | 2/20 | 0.60 |
| ▸ | GAA | P10253 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | MDM4 | O15151 | 1/20 | 0.50 |
| ▸ | MITF | O75030 | 1/20 | 0.50 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8299753 | 0.89 | TDP1 (0.68) | TDP1SMN1; SMN2HTTHPGDGAA | |
| SCHEMBL1367306 | 0.86 | TDP1 (0.65) | TDP1SMN1; SMN2HTTHPGDGAA | |
| SCHEMBL29777391 | 0.84 | SMN1; SMN2 (0.68) | TDP1SMN1; SMN2HTTHPGDGAA | |
| SCHEMBL29777389 | 0.84 | SMN1; SMN2 (0.68) | TDP1SMN1; SMN2HTTHPGDGAA | |
| SCHEMBL975125 | 0.84 | SMN1; SMN2 (0.68) | TDP1SMN1; SMN2HTTHPGDGAA | |
| SCHEMBL28035894 | 0.83 | TDP1 (0.65) | TDP1SMN1; SMN2HTTHPGDGAA | |
| SCHEMBL971803 | 0.82 | TDP1 (0.64) | TDP1SMN1; SMN2HTTHPGDGAA | |
| SCHEMBL27782344 | 0.81 | KDR (0.78) | TDP1SMN1; SMN2HTTHPGDGAA | |
| SCHEMBL27724858 | 0.81 | SMN1; SMN2 (0.60) | TDP1SMN1; SMN2HTTHPGDGAA | |
| SCHEMBL1366221 | 0.80 | GAA (0.59) | TDP1SMN1; SMN2HTTHPGDGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0415304-A2 | Dipyrido[3,2-b:2',3'-e][1,4]oxazepin (and thiazepin)-6(5H)-ones and their use in the prevention or treatment of aids | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 1991-03-06 | — | — | EP | disclosed |