Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28672017 | 0.88 | HTT (0.48) | IDO1HTTRAB9ARIPK1CYP3A4 | |
| Hydrochloric Acid SCHEMBL15101422 | 0.86 | MAPT (0.52) | IDO1HTTRAB9ARIPK1CYP3A4 | |
| SCHEMBL10496418 | 0.80 | EPHX2 (0.44) | HTTRAB9AMEN1KMT2ATP53 | |
| SCHEMBL22472089 | 0.76 | RIPK1 (0.49) | IDO1HTTRAB9ARIPK1CYP3A4 | |
| SCHEMBL7316409 | 0.76 | IDO1 (0.46) | IDO1HTTRIPK1CYP3A4MAPT | |
| SCHEMBL16794547 | 0.75 | MAOB (0.49) | IDO1HTTRAB9AMAPTTP53 | |
| Hydrochloric Acid SCHEMBL11110452 | 0.74 | EPHX2 (0.45) | HTTRAB9ACYP3A4MAPTKDM4E | |
| SCHEMBL6891746 | 0.74 | RIPK1 (0.50) | IDO1HTTRAB9ARIPK1CYP3A4 | |
| SCHEMBL20686991 | 0.74 | RIPK1 (0.50) | IDO1HTTRAB9ARIPK1CYP3A4 | |
| SCHEMBL20163215 | 0.72 | RIPK1 (0.49) | IDO1HTTRAB9ARIPK1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0429149-A1 | Tricyclic pteridinones and a process for their preparation | BERLEX LABORATORIES, INC. (US) | 1991-05-29 | — | — | EP | disclosed |