Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 8/20 | 0.61 |
| ▸ | GART | P22102 | 6/20 | 0.51 |
| ▸ | ATIC | P31939 | 5/20 | 0.51 |
| ▸ | TYMS | P04818 | 3/20 | 0.49 |
| ▸ | SHMT1 | P34896 | 4/20 | 0.48 |
| ▸ | SHMT2 | P34897 | 3/20 | 0.48 |
| ▸ | FOLR2 | P14207 | 2/20 | 0.48 |
| ▸ | FOLR1 | P15328 | 2/20 | 0.48 |
| ▸ | SLC19A1 | P41440 | 2/20 | 0.48 |
| ▸ | SLC46A1 | Q96NT5 | 2/20 | 0.48 |
| ▸ | FRK | P42685 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9844757 | 0.95 | DHFR (0.55) | DHFRGARTATICTYMSSHMT1 | |
| SCHEMBL9844884 | 0.90 | DHFR (0.55) | DHFRGARTATICTYMSSHMT1 | |
| SCHEMBL9844819 | 0.85 | DHFR (0.51) | DHFRGARTATICTYMSSHMT1 | |
| SCHEMBL9844833 | 0.84 | DHFR (0.60) | DHFRGARTATICTYMSSHMT1 | |
| SCHEMBL8982460 | 0.82 | DHFR (0.68) | DHFRGARTATICTYMSSHMT1 | |
| SCHEMBL9844850 | 0.81 | DHFR (0.54) | DHFRGARTATICTYMSSHMT1 | |
| SCHEMBL9844775 | 0.79 | DHFR (0.43) | DHFRGARTATICTYMSSHMT1 | |
| SCHEMBL9844769 | 0.79 | DHFR (0.43) | DHFRGARTATICTYMSSHMT1 | |
| SCHEMBL9844817 | 0.78 | DHFR (0.61) | DHFRGARTATICTYMSSHMT1 | |
| SCHEMBL9844820 | 0.78 | DHFR (0.61) | DHFRGARTATICTYMSSHMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0438261-A2 | Condensed heterocyclic glutamic acid derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1991-07-24 | — | — | EP | claimed |
| EP-0438261-A2 | Condensed heterocyclic glutamic acid derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1991-07-24 | — | — | EP | disclosed |