Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | DHFR | P00374 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28658021 | 0.80 | RAPGEF4 (0.42) | RAPGEF4RAB9ANPC1SOS1SMN1; SMN2 | |
| SCHEMBL19294196 | 0.78 | RAPGEF4 (0.42) | RAPGEF4RAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL12252046 | 0.78 | TNIK (0.41) | RAB9ANPC1MAPTALDH1A1MEN1 | |
| SCHEMBL2119807 | 0.78 | SOS1 (0.61) | RAPGEF4RAB9ANPC1SOS1TRPA1 | |
| SCHEMBL1777858 | 0.74 | RAPGEF4 (0.45) | RAPGEF4RAB9ANPC1SOS1SMN1; SMN2 | |
| SCHEMBL31099069 | 0.74 | RAPGEF4 (0.50) | RAPGEF4RAB9ANPC1SOS1SMN1; SMN2 | |
| SCHEMBL1143594 | 0.74 | SOS1 (0.47) | RAPGEF4RAB9ANPC1SOS1SMN1; SMN2 | |
| SCHEMBL12981083 | 0.74 | RAB9A (0.47) | RAPGEF4RAB9ANPC1SOS1SMN1; SMN2 | |
| SCHEMBL19334300 | 0.74 | RAPGEF4 (0.45) | RAPGEF4RAB9ANPC1SOS1SMN1; SMN2 | |
| SCHEMBL28120099 | 0.74 | RAPGEF4 (0.45) | RAPGEF4RAB9ANPC1SOS1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110003076-A | Sulfamoyl pyrrole amides derivative and its purposes for being used to treat hepatitis B as drug | 爱尔兰詹森科学公司 | 2019-07-12 | — | — | CN | disclosed |
| CN-105452220-B | Sulfamoyl pyrrole amide derivative and application thereof as medicine for treating hepatitis B | 爱尔兰詹森科学公司 | 2019-01-25 | — | — | CN | disclosed |
| CN-105658624-B | Carboxamides derivatives and its purposes for being used to treat hepatitis B as drug | 爱尔兰詹森科学公司 | 2019-01-04 | — | — | CN | disclosed |
| CN-109153651-A | amido-substituted cyclohexane derivatives | 拜耳制药股份公司 | 2019-01-04 | — | — | CN | disclosed |
| CN-106132962-B | Macrocyclic compounds having an aromatic P2' group as factor XIA inhibitors | 百时美施贵宝公司 | 2018-09-07 | — | — | CN | disclosed |
| WO-1991013847-A1 | PROCESS FOR PREPARING CHLORO-DIFLUOROBENZENE | ISC CHEMICALS LIMITED (GB) | 1991-09-19 | — | — | WO | disclosed |
| EP-0447259-A1 | Process for preparing chloro-difluorobenzene | ISC CHEMICALS LIMITED (GB) | 1991-09-18 | — | — | EP | disclosed |
| CN-1009920-B | Halogenated benzoic acid derivatives and their preparation | KYORIN SEIYAKU KK (JP) | 1990-10-10 | — | — | CN | disclosed |
| CN-1008732-B | Benzoyl acetate derivative and preparation method thereof | KYORIN SEIYAKU KK (JP) | 1990-07-11 | — | — | CN | disclosed |
| CN-87100382-A | Benzoylacetic acid ester derivatives and preparation method thereof | — | 1987-09-02 | — | — | CN | disclosed |
| CN-87100387-A | Process for preparing quinolone carboxylic acid derivatives | — | 1987-08-19 | — | — | CN | disclosed |
| CN-87100373-A | Halogenated benzoic acid derivative and preparation thereof | — | 1987-08-19 | — | — | CN | disclosed |