Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLR1 | P15328 | 7/20 | 0.62 |
| ▸ | SLC46A1 | Q96NT5 | 6/20 | 0.59 |
| ▸ | TYMS | P04818 | 3/20 | 0.59 |
| ▸ | FOLR2 | P14207 | 2/20 | 0.59 |
| ▸ | SLC19A1 | P41440 | 2/20 | 0.59 |
| ▸ | DHFR | P00374 | 1/20 | 0.59 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.59 |
| ▸ | GART | P22102 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9844853 | 0.85 | FOLR1 (0.62) | FOLR1SLC46A1TYMSFOLR2SLC19A1 | |
| SCHEMBL9844813 | 0.83 | FOLR1 (0.68) | FOLR1SLC46A1FOLR2SLC19A1GART | |
| SCHEMBL9227335 | 0.78 | TYMS (0.51) | FOLR1SLC46A1TYMSFOLR2SLC19A1 | |
| Raltitrexed SCHEMBL12022787 | 0.77 | TYMS (0.74) | FOLR1SLC46A1TYMSFOLR2SLC19A1 | |
| SCHEMBL9040482 | 0.77 | TYMS (0.55) | FOLR1SLC46A1TYMSFOLR2SLC19A1 | |
| SCHEMBL9844872 | 0.77 | TYMS (0.52) | FOLR1SLC46A1TYMSFOLR2SLC19A1 | |
| SCHEMBL9219313 | 0.76 | FOLR1 (0.52) | FOLR1SLC46A1TYMSFOLR2SLC19A1 | |
| SCHEMBL9226749 | 0.76 | FOLR1 (0.52) | FOLR1SLC46A1TYMSFOLR2SLC19A1 | |
| SCHEMBL9844899 | 0.76 | GART (0.68) | FOLR1SLC46A1FOLR2SLC19A1GART | |
| SCHEMBL9844849 | 0.76 | GART (0.67) | FOLR1SLC46A1TYMSFOLR2SLC19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0438261-A2 | Condensed heterocyclic glutamic acid derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1991-07-24 | — | — | EP | claimed |
| EP-0438261-A2 | Condensed heterocyclic glutamic acid derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1991-07-24 | — | — | EP | disclosed |