Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.53 |
| ▸ | TOP2A | P11388 | 7/20 | 0.56 |
| ▸ | TOP2B | Q02880 | 7/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.54 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | CLK2 | P49760 | 1/20 | 0.54 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.53 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9693064 | 0.99 | TOP2A (0.57) | TOP2ATOP2BKCNH2ALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL9692567 | 0.98 | TOP2A (0.56) | TOP2ATOP2BKCNH2ALDH1A1KDM4E | |
| Formic Acid SCHEMBL9692677 | 0.95 | TOP2A (0.53) | TOP2ATOP2BKCNH2ALDH1A1KDM4E | |
| Bromide SCHEMBL9736884 | 0.93 | KCNH2 (0.53) | TOP2ATOP2BKCNH2ALDH1A1KDM4E | |
| SCHEMBL9693045 | 0.92 | KCNH2 (0.53) | TOP2ATOP2BKCNH2ALDH1A1KDM4E | |
| SCHEMBL9690836 | 0.88 | TOP2A (0.58) | TOP2ATOP2BKCNH2ALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL9693049 | 0.87 | TOP2A (0.57) | TOP2ATOP2BKCNH2ALDH1A1KDM4E | |
| SCHEMBL9844994 | 0.86 | KCNH2 (0.44) | TOP2ATOP2BKCNH2ALDH1A1KDM4E | |
| SCHEMBL9693034 | 0.85 | KCNH2 (0.57) | TOP2ATOP2BKCNH2ALDH1A1KDM4E | |
| SCHEMBL29638251 | 0.85 | ALDH1A1 (0.66) | TOP2ATOP2BKCNH2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0424850-A1 | Quinolone compounds and a process for their preparation | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 1991-05-02 | — | — | EP | disclosed |