Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.69 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 4/20 | 0.56 |
| ▸ | CRHBP | P24387 | 2/20 | 0.56 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.56 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9585493 | 0.87 | HTT (0.65) | KDM4EALDH1A1HSD17B10HPGDCRHBP | |
| SCHEMBL23120422 | 0.86 | KDM4E (0.53) | KDM4EALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL9846091 | 0.86 | ALDH1A1 (0.53) | KDM4EALDH1A1HSD17B10HPGDCRHBP | |
| SCHEMBL23135736 | 0.86 | KDM4E (0.57) | KDM4EALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL9846083 | 0.82 | HTT (0.50) | KDM4EALDH1A1HSD17B10HPGDCRHBP | |
| SCHEMBL20921007 | 0.80 | KDM4E (0.56) | KDM4EALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL3226903 | 0.79 | KDM4E (0.54) | KDM4EALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL4878761 | 0.79 | ALDH1A1 (0.59) | KDM4EALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL23135734 | 0.77 | KDM4E (0.58) | KDM4EALDH1A1HTTNPSR1SMN1; SMN2 | |
| SCHEMBL23135735 | 0.77 | ALDH1A1 (0.57) | KDM4EALDH1A1HSD17B10HTTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10266542-B2 | EZH2 inhibitors | Mirati Therapeutics, Inc. (US) | 2019-04-23 | — | — | US | disclosed |
| EP-0462800-A2 | Inhibitors of HIV reverse transcriptase | MERCK & CO. INC. (US) | 1991-12-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10266542-B2 | EZH2 inhibitors | EZH2, BMI1, EED | KDM4E 27/4885ALDH1A1 1969/4885HSD17B10 2012/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.