Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | ELANE | P08246 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | APLNR | P35414 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | RPA1 | P27694 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5573693 | 0.82 | MAPT (0.54) | MAPTRAB9ANPC1LOXL2TP53 | |
| SCHEMBL9846171 | 0.81 | MAPT (0.40) | MAPTRAB9ANPC1LOXL2TP53 | |
| SCHEMBL9846145 | 0.79 | RAB9A (0.50) | MAPTRAB9ANPC1LOXL2TP53 | |
| SCHEMBL9846412 | 0.77 | RAB9A (0.48) | MAPTRAB9ANPC1LOXL2TP53 | |
| SCHEMBL9846349 | 0.74 | MAPT (0.50) | MAPTRAB9ANPC1LOXL2TP53 | |
| SCHEMBL9846394 | 0.74 | MAPT (0.49) | MAPTRAB9ANPC1LOXL2TP53 | |
| SCHEMBL9846193 | 0.73 | MAPT (0.48) | MAPTRAB9ANPC1LOXL2TP53 | |
| SCHEMBL9268706 | 0.73 | RAB9A (0.48) | MAPTRAB9ANPC1LOXL2TP53 | |
| SCHEMBL9846167 | 0.73 | MAPT (0.48) | MAPTRAB9ANPC1LOXL2TP53 | |
| SCHEMBL9846184 | 0.73 | MAPT (0.48) | MAPTRAB9ANPC1LOXL2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0462800-A2 | Inhibitors of HIV reverse transcriptase | MERCK & CO. INC. (US) | 1991-12-27 | — | — | EP | disclosed |