Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Histamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 2/20 | 0.43 |
| ▸ | MAOB | P27338 | 6/20 | 0.38 |
| ▸ | MAOA | P21397 | 4/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.36 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | HTR1B | P28222 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Histamine SCHEMBL28074178 | 0.89 | HRH1 (0.42) | HRH1TSHRSMN1; SMN2TAAR1HTR2A | |
| Histamine SCHEMBL4234179 | 0.85 | HRH4 (0.39) | HRH1TSHRSMN1; SMN2TAAR1HTR2A | |
| Histamine SCHEMBL27340939 | 0.85 | — | — | |
| Histamine SCHEMBL5447892 | 0.85 | — | — | |
| Histamine SCHEMBL2279 | 0.85 | — | — | |
| Histamine SCHEMBL7444650 | 0.85 | HRH4 (0.42) | HRH1TSHRSMN1; SMN2LOXL2TDP1 | |
| Histamine SCHEMBL289072 | 0.85 | HRH4 (0.42) | HRH1TSHRSMN1; SMN2LOXL2TDP1 | |
| Histamine SCHEMBL1668636 | 0.85 | HRH4 (0.42) | HRH1TSHRSMN1; SMN2LOXL2TDP1 | |
| Histamine SCHEMBL8571326 | 0.85 | HRH1 (0.42) | HRH1TSHRSMN1; SMN2TAAR1HTR2A | |
| Histamine SCHEMBL991718 | 0.83 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0405128-A2 | Polyimide oligomers and blends and method of curing | THE BOEING COMPANY (US) | 1991-01-02 | — | — | EP | disclosed |