SCHEMBL9846469

SCHEMBL9846469

COc1ccc(Cl)c2c1C(=O)c1ccccc1C2=O

nearest known ligand 0.79

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 8/20 0.79
MEN1 O00255 5/20 0.79
KMT2A Q03164 5/20 0.79
ALDH1A1 P00352 4/20 0.79
KDM4E B2RXH2 4/20 0.79
TDP1 Q9NUW8 2/20 0.79
USP2 O75604 2/20 0.79
DUSP3 P51452 1/20 0.79
RAB9A P51151 6/20 0.65
SMN1; SMN2 Q16637 4/20 0.65
MAPK1 P28482 4/20 0.65
ADORA2A P29274 3/20 0.65
POLB P06746 3/20 0.65
NPSR1 Q6W5P4 2/20 0.65
FGB P02675 1/20 0.65
THRB P10828 1/20 0.65
PPARG P37231 1/20 0.65
NCOA2 Q15596 1/20 0.65
NCOA1 Q15788 1/20 0.65
S1PR4 O95977 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
1,4-Dimethoxyanthraquinone SCHEMBL3417221 0.89 MAPT (1.00) MAPTMEN1KMT2AALDH1A1KDM4E
SCHEMBL28115502 0.88 EGFR (0.62) MAPTMEN1KMT2AALDH1A1KDM4E
SCHEMBL11873601 0.83 MAPT (0.61) MAPTMEN1KMT2AALDH1A1KDM4E
SCHEMBL308115 0.82 ADORA2A (0.76) MAPTMEN1KMT2AALDH1A1KDM4E
SCHEMBL11845702 0.82 MAPT (0.53) MAPTMEN1KMT2AALDH1A1KDM4E
SCHEMBL6901121 0.80 MAPT (0.81) MAPTMEN1KMT2AALDH1A1KDM4E
SCHEMBL11581290 0.79 ADORA2A (0.56) MAPTMEN1KMT2AALDH1A1KDM4E
SCHEMBL29494862 0.79 MAPT (0.79) MAPTMEN1KMT2AALDH1A1KDM4E
SCHEMBL28916427 0.79 KMT2A (0.79) MAPTMEN1KMT2AALDH1A1KDM4E
SCHEMBL9846513 0.79 MAPT (0.79) MAPTMEN1KMT2AALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0432095-A1 Anthraquino vat dyestuffs, their preparation and their use CIBA-GEIGY AG (CH) 1991-06-12 EP disclosed
EP-0274458-B1 ANTHRAQUINONE VAT DYESTUFFS, THEIR PREPARATION AND THEIR USE CIBA-GEIGY AG (CH) 1990-09-19 EP disclosed
EP-0274356-B1 VATTABLE 2-ARYL-4,6-DIAMINOPYRIMIDINE CIBA-GEIGY AG (CH) 1990-05-16 EP disclosed
US-4845220-A Vattable 2-aryl-4,6-diaminopyrimidines CIBA-GEIGY CORPORATION 1989-07-04 US disclosed
EP-0274458-A1 Anthraquinone vat dyestuffs, their preparation and their use CIBA-GEIGY AG (CH) 1988-07-13 EP disclosed
US-3972881-A VAT, CELLULOSE CIBA-GEIGY CORPORATION (US) 1976-08-03 US disclosed
US-3935208-A NATURAL OR REGENERATED CELLULOSE ALTERMATT HANS 1976-01-27 US disclosed