Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | HTR2A | P28223 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.52 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4386673 | 0.91 | MAPT (0.57) | MAPTRAB9AHTR2AKCNH2KCNJ1 | |
| SCHEMBL14876975 | 0.84 | HTR2A (0.54) | MAPTRAB9AHTR2AALDH1A1KMT2A | |
| SCHEMBL9223114 | 0.84 | HTR2A (0.60) | MAPTRAB9AHTR2AKCNH2KMT2A | |
| SCHEMBL25236588 | 0.84 | EPHX1 (0.61) | KCNH2KCNJ1EPHX1 | |
| SCHEMBL10062012 | 0.84 | HTR2A (0.56) | MAPTHTR2AALDH1A1KMT2AGAA | |
| SCHEMBL22959846 | 0.84 | HTR2A (0.56) | MAPTHTR2AALDH1A1KMT2AGAA | |
| SCHEMBL6594172 | 0.83 | HTR2A (0.74) | MAPTRAB9AHTR2AKCNH2KCNJ1 | |
| SCHEMBL4660469 | 0.83 | KCNH2 (0.65) | MAPTRAB9AKCNH2KCNJ1ALDH1A1 | |
| SCHEMBL763025 | 0.83 | HTR2A (0.57) | MAPTHTR2AALDH1A1KMT2AGAA | |
| SCHEMBL409598 | 0.83 | HTR2A (0.59) | MAPTHTR2AALDH1A1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0429232-A1 | N-substituted derivatives of 3R,4R-ethyl-[(1-methyl-1H-imidazol-5-yl)methyl]-2-pyrrolidinone | ALLERGAN, INC. (US) | 1991-05-29 | — | — | EP | disclosed |