Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 15/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
| ▸ | FLT1 | P17948 | 1/20 | 0.37 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9846763 | 0.80 | NR1H2 (0.51) | NR1H2BRD4CREBBPNR1H3 | |
| SCHEMBL29631921 | 0.80 | CHRM2 (0.41) | NR1H2NR1H3 | |
| SCHEMBL2133036 | 0.80 | CHRM2 (0.41) | NR1H2NR1H3 | |
| SCHEMBL12570686 | 0.75 | GABRG2 (0.43) | NR1H2NR1H3CA12CA9 | |
| SCHEMBL21657870 | 0.74 | NR1H2 (0.44) | NR1H2BRD4CREBBPNR1H3CA12 | |
| SCHEMBL9846745 | 0.74 | CCNB2 (0.44) | NR1H2KMT2ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3929041 | 0.73 | NR1H2 (0.51) | NR1H2NR1H3 | |
| SCHEMBL759757 | 0.73 | NR1H2 (0.40) | NR1H2MEN1KMT2ACA12CA9 | |
| SCHEMBL30285064 | 0.73 | KMT2A (0.46) | BRD4CREBBPMEN1KMT2ASLC6A4 | |
| SCHEMBL29954668 | 0.72 | NR1H2 (0.40) | NR1H2NR1H3CA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0429257-A2 | Indole derivatives | GLAXO GROUP LIMITED (GB) | 1991-05-29 | — | — | EP | disclosed |