Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 18/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.42 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9846683 | 0.80 | NR1H2 (0.43) | NR1H2BRD4CREBBPNR1H3 | |
| SCHEMBL9846744 | 0.80 | NR1H2 (0.52) | NR1H2BRD4CREBBPNR1H3 | |
| SCHEMBL8820122 | 0.80 | NR1H2 (0.62) | NR1H2NR1H3 | |
| SCHEMBL9846756 | 0.80 | NR1H2 (0.48) | NR1H2MAPTBRD4CREBBPNR1H3 | |
| SCHEMBL19013038 | 0.79 | MAPT (0.46) | NR1H2LMNATP53MAPT | |
| SCHEMBL29631941 | 0.79 | MAPT (0.46) | NR1H2LMNATP53MAPT | |
| SCHEMBL9846745 | 0.78 | CCNB2 (0.44) | NR1H2LMNATP53MAPT | |
| SCHEMBL9846755 | 0.76 | MAPT (0.46) | LMNATP53MAPTBRD4CREBBP | |
| SCHEMBL21657872 | 0.76 | NR1H2 (0.52) | NR1H2BRD4CREBBPNR1H3 | |
| SCHEMBL10173695 | 0.74 | NR1H2 (0.49) | NR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0429257-A2 | Indole derivatives | GLAXO GROUP LIMITED (GB) | 1991-05-29 | — | — | EP | disclosed |