SCHEMBL9846698

SCHEMBL9846698

CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc2[nH]c(-c3ccccc3NS(=O)(=O)C(F)(F)F)c(Br)c2c1

nearest known ligand 0.64

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AGTR1 P30556 1/20 0.51
AGTR2 P50052 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9846719 0.92
SCHEMBL9694873 0.85 AGTR1 (0.67) AGTR1
SCHEMBL9846742 0.82 AGTR1 (0.57) AGTR1AGTR2
SCHEMBL9678093 0.81
SCHEMBL9309133 0.78
SCHEMBL3627824 0.78 AGTR2 (0.56) AGTR2
SCHEMBL9310151 0.78
SCHEMBL9310012 0.77
SCHEMBL9846718 0.76 AGTR1 (0.69) AGTR1AGTR2
SCHEMBL9309237 0.76 AGTR2 (0.44) AGTR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0429257-A2 Indole derivatives GLAXO GROUP LIMITED (GB) 1991-05-29 EP claimed
EP-0429257-A2 Indole derivatives GLAXO GROUP LIMITED (GB) 1991-05-29 EP disclosed