Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 5/20 | 0.70 |
| ▸ | GSK3B | P49841 | 4/20 | 0.70 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.70 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.70 |
| ▸ | GSK3A | P49840 | 3/20 | 0.70 |
| ▸ | RPS6KA5 | O75582 | 3/20 | 0.70 |
| ▸ | AKT1 | P31749 | 3/20 | 0.70 |
| ▸ | NEK4 | P51957 | 3/20 | 0.70 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.70 |
| ▸ | PRKG2 | Q13237 | 3/20 | 0.70 |
| ▸ | PRKG1 | Q13976 | 3/20 | 0.70 |
| ▸ | PKN2 | Q16513 | 3/20 | 0.70 |
| ▸ | PRKACA | P17612 | 2/20 | 0.70 |
| ▸ | PRKX | P51817 | 2/20 | 0.70 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.70 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.70 |
| ▸ | PRKCG | P05129 | 2/20 | 0.70 |
| ▸ | CDK1 | P06493 | 2/20 | 0.70 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.70 |
| ▸ | CDK2 | P24941 | 2/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2777735 | 1.00 | ROCK2 (0.70) | ROCK2GSK3BROCK1CLK4GSK3A | |
| SCHEMBL9293287 | 1.00 | ROCK2 (0.70) | ROCK2GSK3BROCK1CLK4GSK3A | |
| Hydrochloric Acid SCHEMBL29693063 | 0.98 | GSK3B (0.68) | ROCK2GSK3BROCK1CLK4GSK3A | |
| SCHEMBL28015865 | 0.89 | KDM4E (0.78) | ROCK2GSK3BROCK1CLK4GSK3A | |
| SCHEMBL12302081 | 0.89 | MAPK1 (0.66) | ROCK2GSK3BROCK1CLK4GSK3A | |
| SCHEMBL14427964 | 0.89 | MAPK1 (0.66) | ROCK2GSK3BROCK1CLK4GSK3A | |
| SCHEMBL16680227 | 0.89 | ROCK2 (0.66) | ROCK2GSK3BROCK1CLK4GSK3A | |
| SCHEMBL12302084 | 0.89 | MAPK1 (0.66) | ROCK2GSK3BROCK1CLK4GSK3A | |
| SCHEMBL16680225 | 0.89 | ROCK2 (0.66) | ROCK2GSK3BROCK1CLK4GSK3A | |
| SCHEMBL27791608 | 0.86 | ROCK1 (0.72) | ROCK2GSK3BROCK1CLK4GSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0459730-A2 | Anti-tumour compounds | ZENECA LIMITED (GB) | 1991-12-04 | — | — | EP | disclosed |