Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 5/20 | 0.66 |
| ▸ | GSK3B | P49841 | 4/20 | 0.66 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.66 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.66 |
| ▸ | GSK3A | P49840 | 3/20 | 0.66 |
| ▸ | RPS6KA5 | O75582 | 3/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.66 |
| ▸ | AKT1 | P31749 | 3/20 | 0.66 |
| ▸ | NEK4 | P51957 | 3/20 | 0.66 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.66 |
| ▸ | PRKG2 | Q13237 | 3/20 | 0.66 |
| ▸ | PRKG1 | Q13976 | 3/20 | 0.66 |
| ▸ | PKN2 | Q16513 | 3/20 | 0.66 |
| ▸ | PRKACA | P17612 | 2/20 | 0.66 |
| ▸ | PRKX | P51817 | 2/20 | 0.66 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.66 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.66 |
| ▸ | PRKCG | P05129 | 2/20 | 0.66 |
| ▸ | CDK1 | P06493 | 2/20 | 0.66 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16680225 | 1.00 | ROCK2 (0.66) | ROCK2GSK3BROCK1CLK4GSK3A | |
| SCHEMBL9848822 | 0.89 | ROCK2 (0.70) | ROCK2GSK3BROCK1CLK4GSK3A | |
| SCHEMBL9293287 | 0.89 | ROCK2 (0.70) | ROCK2GSK3BROCK1CLK4GSK3A | |
| SCHEMBL2777735 | 0.89 | ROCK2 (0.70) | ROCK2GSK3BROCK1CLK4GSK3A | |
| Hydrochloric Acid SCHEMBL29693063 | 0.87 | GSK3B (0.68) | ROCK2GSK3BROCK1CLK4GSK3A | |
| SCHEMBL14427964 | 0.84 | MAPK1 (0.66) | ROCK2GSK3BROCK1CLK4GSK3A | |
| SCHEMBL12302084 | 0.84 | MAPK1 (0.66) | ROCK2GSK3BROCK1CLK4GSK3A | |
| SCHEMBL12302081 | 0.84 | MAPK1 (0.66) | ROCK2GSK3BROCK1CLK4GSK3A | |
| SCHEMBL28015865 | 0.84 | KDM4E (0.78) | ROCK2GSK3BROCK1CLK4GSK3A | |
| SCHEMBL8305694 | 0.84 | ALDH1A1 (0.66) | ROCK2GSK3BROCK1CLK4GSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10660888-B2 | Aminoheteroaryl benzamides as kinase inhibitors | NOVARTIS AG (CH) | 2020-05-26 | — | — | US | disclosed |
| US-20190247392-A1 | AMINOHETEROARYL BENZAMIDES AS KINASE INHIBITORS | NOVARTIS VACCINES AND DIAGNOSTICS, INC. | 2019-08-15 | — | — | US | disclosed |
| US-10188649-B2 | Aminoheteroaryl benzamides as kinase inhibitors | NOVARTIS AG (CH) | 2019-01-29 | — | — | US | disclosed |
| EP-3063143-B1 | AMINOHETEROARYL BENZAMIDES AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2018-05-16 | — | — | EP | disclosed |
| US-20180028532-A1 | AMINOHETEROARYL BENZAMIDES AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2018-02-01 | — | — | US | disclosed |
| US-9763937-B2 | Aminoheteroaryl benzamides as kinase inhibitors | NOVARTIS AG (CH) | 2017-09-19 | — | — | US | disclosed |
| US-20170182038-A1 | AMINOHETEROARYL BENZAMIDES AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2017-06-29 | — | — | US | disclosed |
| EP-3063143-A1 | AMINOHETEROARYL BENZAMIDES AS KINASE INHIBITORS | Novartis AG (CH) | 2016-09-07 | — | — | EP | disclosed |
| US-9242996-B2 | Aminoheteroaryl benzamides as kinase inhibitors | NOVARTIS AG (CH) | 2016-01-26 | — | — | US | disclosed |
| US-20150126490-A1 | AMINOHETEROARYL BENZAMIDES AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2015-05-07 | — | — | US | disclosed |
| WO-2015066188-A1 | AMINOHETEROARYL BENZAMIDES AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2015-05-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190247392-A1 | AMINOHETEROARYL BENZAMIDES AS KINASE INHIBITORS | ABL1, MAP3K12, MAP3K2 | ROCK2 294/4885GSK3B 347/4885ROCK1 427/4885 |
| US-20150126490-A1 | AMINOHETEROARYL BENZAMIDES AS KINASE INHIBITORS | ABL1, MAP3K12, MAP3K2 | ROCK2 294/4885GSK3B 347/4885ROCK1 427/4885 |
| US-10188649-B2 | Aminoheteroaryl benzamides as kinase inhibitors | ABL1, MAP3K12, MAP3K2 | ROCK2 294/4885GSK3B 347/4885ROCK1 427/4885 |
| US-10660888-B2 | Aminoheteroaryl benzamides as kinase inhibitors | ABL1, MAP3K12, MAP3K2 | ROCK2 294/4885GSK3B 347/4885ROCK1 427/4885 |
| US-20170182038-A1 | AMINOHETEROARYL BENZAMIDES AS KINASE INHIBITORS | ABL1, MAP3K12, MAP3K2 | ROCK2 294/4885GSK3B 347/4885ROCK1 427/4885 |
| US-20180028532-A1 | AMINOHETEROARYL BENZAMIDES AS KINASE INHIBITORS | ABL1, MAP3K12, MAP3K2 | ROCK2 294/4885GSK3B 347/4885ROCK1 427/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.