Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 6/20 | 0.40 |
| ▸ | CTSA | P10619 | 1/20 | 0.38 |
| ▸ | HMGCR | P04035 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.37 |
| ▸ | DHFR | P00374 | 1/20 | 0.36 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8877954 | 0.88 | DHODH (0.43) | DHODHCTSAHMGCRDHFRALKBH5 | |
| SCHEMBL9849142 | 0.84 | HMGCR (0.40) | DHODHCTSAHMGCR | |
| SCHEMBL9849071 | 0.83 | HMGCR (0.37) | DHODHCTSAHMGCR | |
| SCHEMBL9849132 | 0.81 | HMGCR (0.36) | DHODHCTSAHMGCR | |
| SCHEMBL8877555 | 0.74 | HMGCR (0.48) | HMGCR | |
| SCHEMBL8879993 | 0.73 | HMGCR (0.49) | DHODHHMGCR | |
| SCHEMBL9849110 | 0.73 | KMT2A (0.48) | DHODH | |
| SCHEMBL8877862 | 0.72 | HMGCR (0.44) | DHODHHMGCR | |
| SCHEMBL9849239 | 0.71 | HMGCR (0.48) | DHODHHMGCR | |
| SCHEMBL9849224 | 0.70 | DHODH (0.45) | DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0444533-A2 | Quinoline and pyridine anchors for HMG-CoA reductase inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1991-09-04 | — | — | EP | disclosed |