Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | NCEH1 | Q6PIU2 | 6/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PRNP | P04156 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7153174 | 0.82 | NPC1 (0.48) | ALDH1A1HPGDNCEH1SMN1; SMN2NPC1 | |
| SCHEMBL9849254 | 0.77 | GAA (0.39) | HPGDSMN1; SMN2NPC1MAPTRAB9A | |
| SCHEMBL9849200 | 0.76 | NCEH1 (0.52) | ALDH1A1HPGDNCEH1SMN1; SMN2NPC1 | |
| SCHEMBL9849106 | 0.73 | ALDH1A1 (0.45) | ALDH1A1HPGDNCEH1SMN1; SMN2NPC1 | |
| SCHEMBL5295117 | 0.73 | MAPT (0.51) | ALDH1A1NCEH1SMN1; SMN2NPC1MAPT | |
| SCHEMBL21690088 | 0.73 | MAPT (0.51) | ALDH1A1NCEH1SMN1; SMN2NPC1MAPT | |
| SCHEMBL9849111 | 0.72 | POLB (0.37) | ALDH1A1HPGDNPC1MAPTRAB9A | |
| SCHEMBL7322093 | 0.72 | CTNNB1 (0.60) | ALDH1A1HPGDKDM4EMMP8CTNNB1 | |
| SCHEMBL6655998 | 0.72 | ALDH1A1 (0.53) | ALDH1A1HPGDNCEH1SMN1; SMN2NPC1 | |
| SCHEMBL7061781 | 0.70 | PRNP (0.42) | ALDH1A1HPGDNCEH1SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0421436-A2 | Substituted carboxytetrahydroisoquinolines and derivatives thereof having pharmaceutical activity | WARNER-LAMBERT COMPANY (US) | 1991-04-10 | — | — | EP | disclosed |