Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.37 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9849111 | 0.85 | POLB (0.37) | GAAHSD17B10LMNAMAPTMAPK1 | |
| SCHEMBL9849115 | 0.77 | ALDH1A1 (0.43) | LMNAMAPTMMP8HPGDNPC1 | |
| SCHEMBL9849163 | 0.70 | ALDH1A1 (0.44) | GAAHSD17B10LMNAMAPTMAPK1 | |
| SCHEMBL19502670 | 0.69 | MMP8 (0.54) | MMP8CYP4F2CYP4A11NPC1SMN1; SMN2 | |
| SCHEMBL11689327 | 0.69 | CYP4F2 (0.42) | GAAHSD17B10LMNAMAPTMAPK1 | |
| SCHEMBL27629136 | 0.68 | CYP4F2 (0.55) | HSD17B10LMNACYP4F2CYP4A11SMN1; SMN2 | |
| SCHEMBL28914938 | 0.68 | MMP8 (0.48) | HSD17B10LMNAMAPTMAPK1MMP8 | |
| SCHEMBL10696109 | 0.67 | KMT2A (0.58) | GAAHSD17B10LMNAMAPTMAPK1 | |
| SCHEMBL7425430 | 0.67 | MEN1 (0.44) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL11900967 | 0.66 | MMP8 (0.49) | MAPK1MMP8PPARGPPARANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0421436-A2 | Substituted carboxytetrahydroisoquinolines and derivatives thereof having pharmaceutical activity | WARNER-LAMBERT COMPANY (US) | 1991-04-10 | — | — | EP | disclosed |