Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRNP | P04156 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | NCEH1 | Q6PIU2 | 3/20 | 0.41 |
| ▸ | CDC25B | P30305 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CDC25A | P30304 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6655998 | 0.79 | ALDH1A1 (0.53) | PRNPRXFP1SMN1; SMN2NPC1MAPT | |
| SCHEMBL7153174 | 0.77 | NPC1 (0.48) | PRNPRXFP1SMN1; SMN2NPC1MAPT | |
| SCHEMBL9849200 | 0.76 | NCEH1 (0.52) | PRNPRXFP1SMN1; SMN2NPC1MAPT | |
| SCHEMBL10391564 | 0.76 | ALDH1A1 (0.46) | PRNPRXFP1SMN1; SMN2NPC1MAPT | |
| SCHEMBL9849278 | 0.75 | KDM4E (0.38) | SMN1; SMN2MAPTHPGDALDH1A1NCEH1 | |
| SCHEMBL7060600 | 0.75 | PRNP (0.44) | PRNPRXFP1SMN1; SMN2NPC1MAPT | |
| SCHEMBL30640504 | 0.74 | GABRA1 (0.52) | SMN1; SMN2NPC1MAPTRAB9AHPGD | |
| SCHEMBL8850092 | 0.74 | GABRA1 (0.52) | SMN1; SMN2NPC1MAPTRAB9AHPGD | |
| SCHEMBL7057912 | 0.74 | PRNP (0.41) | PRNPRXFP1SMN1; SMN2NPC1MAPT | |
| SCHEMBL7057910 | 0.74 | PRNP (0.41) | PRNPRXFP1SMN1; SMN2NPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0421436-A2 | Substituted carboxytetrahydroisoquinolines and derivatives thereof having pharmaceutical activity | WARNER-LAMBERT COMPANY (US) | 1991-04-10 | — | — | EP | disclosed |