⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5560931 | 0.97 | TSHR (0.40) | — | |
| SCHEMBL5566492 | 0.93 | — | — | |
| SCHEMBL23142259 | 0.74 | PNMT (0.40) | — | |
| SCHEMBL3709002 | 0.70 | — | — | |
| SCHEMBL182363 | 0.69 | — | — | |
| SCHEMBL2875172 | 0.68 | MAOA (0.48) | — | |
| SCHEMBL9295831 | 0.66 | CYP2A6 (0.50) | — | |
| SCHEMBL1760720 | 0.65 | TSHR (0.50) | — | |
| SCHEMBL21962355 | 0.63 | CYP1A2 (0.36) | — | |
| SCHEMBL25202453 | 0.62 | CDC25B (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 117 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115093428-B | 2, 6-dioxaspiro [4,5] decane derivatives, preparation method and application thereof in medicine | 山东绿叶制药有限公司 | 2023-09-22 | — | — | CN | claimed |
| CN-115093428-A | 2, 6-dioxaspiro [4,5] decane derivative, preparation method and medical application thereof | 山东绿叶制药有限公司 | 2022-09-23 | — | — | CN | claimed |
| US-11124523-B2 | 2,6-dioxaspiro [4,5] decane derivatives and preparation method therefor and pharmaceutical applications thereof | SHANDONG LUYE PHARMACEUTICAL CO., LTD. | 2021-09-21 | — | — | US | claimed |
| US-20200255444-A1 | 2,6-DIOXASPIRO [4,5] DECANE DERIVATIVES AND PREPARATION METHOD THEREFOR AND PHARMACEUTICAL APPLICATIONS THEREOF | SHANDONG LUYE PHARMACEUTICAL CO., LTD. (CN) | 2020-08-13 | — | — | US | claimed |
| CN-111148515-A | 2, 6-dioxaspiro [4,5] decane derivative, preparation method and medical application thereof | 山东绿叶制药有限公司 | 2020-05-12 | — | — | CN | claimed |
| US-20050107350-A1 | Method for the treatment or prevention of bone disorders with a cyclooxygenase-2 inhibitor alone and in combination with a bone disorder treatment agent and compositions therewith | PHARMACIA CORPORATION (US) | 2005-05-19 | — | — | US | claimed |
| US-20040254158-A1 | Anticoagulants; atherosclerosis; strokes; thrombosis; cardiovascular disorders | BRISTOL-MYERS SQUIBB COMPANY | 2004-12-16 | — | — | US | claimed |
| WO-2025097104-A1 | THIENYL COMPOUNDS FOR THE TREATMENT OF A CENTRAL NERVOUS SYSTEM DISEASE OR DISORDER | PGI DRUG DISCOVERY LLC (US) | 2025-05-08 | — | — | WO | disclosed |
| CN-115093428-B | 2, 6-dioxaspiro [4,5] decane derivatives, preparation method and application thereof in medicine | 山东绿叶制药有限公司 | 2023-09-22 | — | — | CN | disclosed |
| WO-2023106405-A1 | COMPOUND, ORGANIC SEMICONDUCTOR MATERIAL, AND ORGANIC ELECTRONIC DEVICE | 国立大学法人大阪大学 | 2023-06-15 | — | — | WO | disclosed |
| US-11569530-B2 | Silicon-based energy storage devices with functional thiophene compounds or derivatives of thiophene containing electrolyte additives | ENEVATE CORPORATION (US) | 2023-01-31 | — | — | US | disclosed |
| CN-115093428-A | 2, 6-dioxaspiro [4,5] decane derivative, preparation method and medical application thereof | 山东绿叶制药有限公司 | 2022-09-23 | — | — | CN | disclosed |
| CN-111148515-B | 2, 6-dioxaspiro [4,5] decane derivative, preparation method and medical application thereof | 山东绿叶制药有限公司 | 2022-07-19 | — | — | CN | disclosed |
| EP-0418071-B1 | New N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase | PFIZER (US) | 1995-04-26 | — | — | EP | disclosed |
| US-5362878-A | Intermediates for making N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT) | PFIZER INC. (US) | 1994-11-08 | — | — | US | disclosed |
| EP-0609960-A1 | New N-heteroarylamide derivatives as inhibitors of acyl coenzyme A: cholestrol acyl transferase | PFIZER INC. (US) | 1994-08-10 | — | — | EP | disclosed |
| WO-1991004027-A1 | NEW N-ARYL AND N-HETEROARYLAMIDE AND UREA DERIVATIVES AS INHIBITORS OF ACYL COENZYME A: CHOLESTEROL ACYL TRANSFERASE (ACAT) | PFIZER INC. (US) | 1991-04-04 | — | — | WO | disclosed |
| EP-0418071-A2 | New N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase | PFIZER INC. (US) | 1991-03-20 | — | — | EP | disclosed |
| US-4711742-A | Solution processible forms of neutral and electrically conductive poly(substituted heterocycles) | ALLIED CORPORATION (US) | 1987-12-08 | — | — | US | disclosed |
| EP-0203438-A1 | Solution processible forms of neutral and electrically conductive poly(substituted heterocycles) | ALLIED CORPORATION (US) | 1986-12-03 | — | — | EP | disclosed |