Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TGM2 | P21980 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.39 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.39 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.39 |
| ▸ | FDPS | P14324 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9849436 | 0.93 | HTT (0.46) | HTTLMNASMN1; SMN2TGM2KEAP1 | |
| SCHEMBL3726894 | 0.85 | HTT (0.60) | HTTLMNASMN1; SMN2TGM2KEAP1 | |
| SCHEMBL9193612 | 0.83 | HTT (0.46) | HTTLMNASMN1; SMN2TGM2KEAP1 | |
| SCHEMBL9189809 | 0.82 | HTT (0.46) | HTTLMNASMN1; SMN2TGM2KEAP1 | |
| SCHEMBL8038121 | 0.79 | HTT (0.55) | HTTLMNASMN1; SMN2TGM2KEAP1 | |
| SCHEMBL8050960 | 0.78 | HTT (0.52) | HTTLMNASMN1; SMN2TGM2KEAP1 | |
| SCHEMBL9190671 | 0.78 | LMNA (0.58) | HTTLMNASMN1; SMN2TGM2KEAP1 | |
| SCHEMBL9190225 | 0.78 | HTT (0.45) | HTTLMNASMN1; SMN2TGM2KEAP1 | |
| SCHEMBL8050193 | 0.78 | HTT (0.54) | HTTLMNASMN1; SMN2TGM2KEAP1 | |
| SCHEMBL9193616 | 0.77 | HTT (0.48) | HTTLMNASMN1; SMN2TGM2KEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0416689-A2 | Acyloxymethyl esters of bisphosphonic acids as bone resorption inhibitors | MERCK & CO. INC. (US) | 1991-03-13 | — | — | EP | disclosed |