Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 3/20 | 0.51 |
| ▸ | FOLR2 | P14207 | 1/20 | 0.37 |
| ▸ | FOLR1 | P15328 | 1/20 | 0.37 |
| ▸ | GART | P22102 | 1/20 | 0.37 |
| ▸ | SLC19A1 | P41440 | 1/20 | 0.37 |
| ▸ | DHFR | P00374 | 4/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.31 |
| ▸ | LDHA | P00338 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9849722 | 0.92 | DAO (0.46) | DAOFOLR2FOLR1GARTSLC19A1 | |
| SCHEMBL9849630 | 0.92 | DAO (0.46) | DAOFOLR2FOLR1GARTSLC19A1 | |
| SCHEMBL9850021 | 0.91 | DAO (0.45) | DAOFOLR2FOLR1GARTSLC19A1 | |
| SCHEMBL9849678 | 0.88 | DAO (0.38) | DAOFOLR2FOLR1GARTSLC19A1 | |
| SCHEMBL9850059 | 0.81 | FOLR2 (0.39) | DAOFOLR2FOLR1GARTSLC19A1 | |
| SCHEMBL9850000 | 0.81 | FOLR2 (0.37) | DAOFOLR2FOLR1GARTSLC19A1 | |
| SCHEMBL9849648 | 0.80 | FOLR2 (0.37) | DAOFOLR2FOLR1GARTSLC19A1 | |
| SCHEMBL9849802 | 0.77 | DAO (0.37) | DAOFOLR2FOLR1GARTSLC19A1 | |
| SCHEMBL9849782 | 0.75 | FOLR1 (0.41) | DAOFOLR1DHFRCYP2D6MAPT | |
| SCHEMBL27908407 | 0.72 | CYP2D6 (0.62) | DHFRCYP2D6ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0415510-A2 | L-glutamic acid derivatives | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1991-03-06 | — | — | EP | disclosed |
| US-4920125-A | L-glutamic acid derivatives | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1990-04-24 | — | — | US | disclosed |