Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLR2 | P14207 | 2/20 | 0.37 |
| ▸ | FOLR1 | P15328 | 2/20 | 0.37 |
| ▸ | GART | P22102 | 2/20 | 0.37 |
| ▸ | SLC19A1 | P41440 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | DHFR | P00374 | 4/20 | 0.35 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
| ▸ | SLC46A1 | Q96NT5 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9850000 | 0.99 | FOLR2 (0.37) | FOLR2FOLR1GARTSLC19A1CYP2D6 | |
| SCHEMBL9850059 | 0.97 | FOLR2 (0.39) | FOLR2FOLR1GARTSLC19A1CYP2D6 | |
| SCHEMBL9849678 | 0.92 | DAO (0.38) | FOLR2FOLR1GARTSLC19A1CYP2D6 | |
| SCHEMBL9850021 | 0.89 | DAO (0.45) | FOLR2FOLR1GARTSLC19A1CYP2D6 | |
| SCHEMBL9849722 | 0.87 | DAO (0.46) | FOLR2FOLR1GARTSLC19A1CYP2D6 | |
| SCHEMBL9849630 | 0.85 | DAO (0.46) | FOLR2FOLR1GARTSLC19A1CYP2D6 | |
| SCHEMBL9849601 | 0.81 | DHFR (0.31) | FOLR2FOLR1GARTSLC19A1DHFR | |
| SCHEMBL9849797 | 0.80 | DAO (0.51) | FOLR2FOLR1GARTSLC19A1CYP2D6 | |
| SCHEMBL9341073 | 0.79 | CYP4A11 (0.53) | CYP2D6DHFR | |
| SCHEMBL9849766 | 0.79 | HPGD (0.44) | FOLR1CYP2D6DHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0415510-A2 | L-glutamic acid derivatives | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1991-03-06 | — | — | EP | disclosed |
| US-4920125-A | L-glutamic acid derivatives | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1990-04-24 | — | — | US | disclosed |