Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA | P10276 | 6/20 | 0.48 |
| ▸ | RARB | P10826 | 6/20 | 0.48 |
| ▸ | RARG | P13631 | 6/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RXRA | P19793 | 2/20 | 0.40 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.40 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.40 |
| ▸ | STAT3 | P40763 | 1/20 | 0.38 |
| ▸ | HNF4A | P41235 | 1/20 | 0.38 |
| ▸ | SSTR5 | P35346 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.35 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8759267 | 0.90 | RARA (0.42) | RARARARBRARGALDH1A1MAPK1 | |
| SCHEMBL7681598 | 0.88 | KDM4E (0.46) | RARARARBRARGRXRACYP26A1 | |
| SCHEMBL7682166 | 0.78 | LMNA (0.39) | AKR1B1 | |
| SCHEMBL28347731 | 0.76 | RARA (0.54) | RARARARBRARGALDH1A1MAPK1 | |
| SCHEMBL30353220 | 0.76 | RARA (0.54) | RARARARBRARGALDH1A1MAPK1 | |
| SCHEMBL23706073 | 0.75 | RARB (0.54) | RARARARBRARGALDH1A1MAPK1 | |
| SCHEMBL23706054 | 0.75 | RARB (0.54) | RARARARBRARGALDH1A1MAPK1 | |
| SCHEMBL30041725 | 0.75 | RARB (0.54) | RARARARBRARGALDH1A1MAPK1 | |
| SCHEMBL23705297 | 0.75 | RARB (0.54) | RARARARBRARGALDH1A1MAPK1 | |
| SCHEMBL7675314 | 0.75 | AKR1B1 (0.30) | AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0435681-A1 | Chroman esters of phenols and benzoic acids having retinoid-like activity | ALLERGAN, INC. (US) | 1991-07-03 | — | — | EP | disclosed |
| US-5006550-A | Skin disorder, arthritis, wound healing agents, dry eye syndrome | ALLERGAN, INC. (US) | 1991-04-09 | — | — | US | disclosed |