Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 11/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16540227 | 0.93 | MAPT (0.49) | TNFMAPTNPC1TP53RAB9A | |
| SCHEMBL9850887 | 0.81 | TNF (0.46) | TNFMAPTGAAKDM4ECNR2 | |
| SCHEMBL20324958 | 0.81 | MAPT (0.50) | MAPTNPC1TP53RAB9ASMN1; SMN2 | |
| SCHEMBL7429783 | 0.81 | ALOX15 (0.59) | TNFSMN1; SMN2KDM4E | |
| SCHEMBL20372453 | 0.80 | NPC1 (0.49) | MAPTNPC1TP53RAB9ASMN1; SMN2 | |
| SCHEMBL30059278 | 0.78 | NPC1 (0.52) | MAPTNPC1TP53RAB9ASMN1; SMN2 | |
| SCHEMBL9850718 | 0.76 | HCRTR1 (0.62) | TP53RAB9ASMN1; SMN2GAAKDM4E | |
| SCHEMBL15757029 | 0.76 | CHRM1 (0.47) | MAPTNPC1TP53RAB9ASMN1; SMN2 | |
| SCHEMBL21162380 | 0.75 | NPC1 (0.55) | MAPTNPC1TP53RAB9ASMN1; SMN2 | |
| SCHEMBL30058616 | 0.75 | NPC1 (0.55) | MAPTNPC1TP53RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0416740-A2 | Novel compounds with renin-inhibiting activity | Beecham Group p.l.c. (GB) | 1991-03-13 | — | — | EP | disclosed |