Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL8531789 | 1.00 | HIF1A (0.33) | HIF1A | |
| Iodide SCHEMBL8528561 | 0.83 | HIF1A (0.34) | HIF1A | |
| Iodide SCHEMBL8528705 | 0.81 | HIF1A (0.38) | HIF1A | |
| Iodide SCHEMBL8532159 | 0.77 | HIF1A (0.34) | HIF1A | |
| Iodide SCHEMBL8528635 | 0.76 | HIF1A (0.46) | HIF1A | |
| Iodide SCHEMBL8528522 | 0.75 | CYP2D6 (0.38) | HIF1A | |
| Iodide SCHEMBL8038349 | 0.72 | LMNA (0.33) | HIF1A | |
| Iodide SCHEMBL8531750 | 0.71 | IDO1 (0.33) | — | |
| Iodide SCHEMBL8529368 | 0.71 | ACP3 (0.38) | — | |
| Iodide SCHEMBL8529133 | 0.70 | TRPA1 (0.33) | HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0428286-A2 | 24- and 25-substituted avermectin and milbemycin derivatives | MERCK & CO. INC. (US) | 1991-05-22 | — | — | EP | disclosed |