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SCHEMBL9851004

SCHEMBL9851004

COc1ccccc1N(C(=O)NCC(=O)Nc1c(C(C)C)cccc1C(C)C)C(c1ccccc1)c1ccccc1

nearest known ligand 0.51

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 3/20 0.51
▸ MEN1 O00255 2/20 0.51
▸ LPAR1 Q92633 5/20 0.50
▸ PKM P14618 1/20 0.44
▸ LMNA P02545 1/20 0.43
▸ SMN1; SMN2 Q16637 1/20 0.43
▸ KDM4E B2RXH2 1/20 0.42
▸ SOAT2 O75908 1/20 0.42
▸ SOAT1 P35610 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9680252 0.78 LPAR1 (0.58) KMT2AMEN1LPAR1PKMLMNA
SCHEMBL9681089 0.77 KMT2A (0.57) KMT2AMEN1LPAR1LMNASMN1; SMN2
SCHEMBL9680708 0.75 LPAR1 (0.49) KMT2AMEN1LPAR1SMN1; SMN2SOAT2
SCHEMBL9680727 0.74 SMN1; SMN2 (0.60) KMT2AMEN1LPAR1LMNASMN1; SMN2
SCHEMBL9678803 0.74 KMT2A (0.50) KMT2AMEN1LMNASMN1; SMN2SOAT2
SCHEMBL9679595 0.71 NLRP3 (0.49) KMT2AMEN1SMN1; SMN2KDM4E
SCHEMBL9679362 0.70 KMT2A (0.63) KMT2AMEN1LMNASMN1; SMN2KDM4E
SCHEMBL9678933 0.70 KMT2A (0.63) KMT2AMEN1LMNASMN1; SMN2KDM4E
SCHEMBL9678585 0.70 KMT2A (0.63) KMT2AMEN1LMNASMN1; SMN2KDM4E
SCHEMBL9678591 0.70 KMT2A (0.63) KMT2AMEN1LMNASMN1; SMN2KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0415413-A1 Acat inhibitors WARNER-LAMBERT COMPANY (US) 1991-03-06 — — EP claimed