Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.65 |
| ▸ | TP53 | P04637 | 1/20 | 0.65 |
| ▸ | PLA2G4B | P0C869 | 5/20 | 0.63 |
| ▸ | PKM | P14618 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.61 |
| ▸ | USP2 | O75604 | 1/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | RARB | P10826 | 4/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | APEX1 | P27695 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16156097 | 0.93 | TSHR (0.71) | TSHRTP53PLA2G4BPKMMAPK1 | |
| SCHEMBL14683447 | 0.93 | TSHR (0.71) | TSHRTP53PLA2G4BPKMMAPK1 | |
| SCHEMBL15849204 | 0.93 | TSHR (0.71) | TSHRTP53PLA2G4BPKMMAPK1 | |
| SCHEMBL28881844 | 0.93 | TSHR (0.71) | TSHRTP53PLA2G4BPKMMAPK1 | |
| SCHEMBL16156094 | 0.93 | TSHR (0.71) | TSHRTP53PLA2G4BPKMMAPK1 | |
| SCHEMBL20148862 | 0.87 | L3MBTL1 (0.79) | ALOX15HSD17B10L3MBTL1POLBALDH1A1 | |
| SCHEMBL522153 | 0.87 | L3MBTL1 (0.61) | TSHRTP53PLA2G4BPKMMAPK1 | |
| SCHEMBL2231223 | 0.85 | PKM (0.67) | TSHRTP53PLA2G4BPKMMAPK1 | |
| SCHEMBL1952122 | 0.85 | TP53 (0.79) | TSHRTP53PLA2G4BPKMMAPK1 | |
| SCHEMBL118037 | 0.85 | PKM (0.77) | TSHRTP53PLA2G4BPKMMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1324359-A | Tricyclic carboxamides | SMITHKLINE BEECHAM PLC (GB) | 2001-11-28 | — | — | CN | disclosed |
| EP-0428268-A2 | Pharmaceutical phenylpyridone derivatives | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1991-05-22 | — | — | EP | disclosed |