Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A12 | P48065 | 3/20 | 1.00 |
| ▸ | SLC6A13 | Q9NSD5 | 2/20 | 1.00 |
| ▸ | ACHE | P22303 | 2/20 | 0.84 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.73 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.73 |
| ▸ | HTT | P42858 | 1/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.70 |
| ▸ | DRD4 | P21917 | 1/20 | 0.69 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 1/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9870485 | 0.89 | SLC6A12 (0.80) | SLC6A12SLC6A13ACHESIGMAR1MCHR1 | |
| SCHEMBL9852144 | 0.86 | SLC6A12 (0.76) | SLC6A12SLC6A13ACHEMCHR1DRD4 | |
| SCHEMBL31736417 | 0.83 | MCHR1 (0.77) | SLC6A12SLC6A13SIGMAR1MCHR1DRD4 | |
| SCHEMBL18658160 | 0.83 | HTT (1.00) | SLC6A12SLC6A13ACHESIGMAR1MCHR1 | |
| SCHEMBL61848 | 0.82 | TMEM97 (0.83) | SLC6A12SLC6A13SIGMAR1MCHR1SMN1; SMN2 | |
| SCHEMBL694949 | 0.82 | SIGMAR1 (0.82) | SLC6A12SLC6A13SIGMAR1MCHR1SMN1; SMN2 | |
| SCHEMBL17946338 | 0.81 | KMT2A (0.80) | SLC6A12SLC6A13ACHESIGMAR1MCHR1 | |
| SCHEMBL2956225 | 0.81 | SLC6A12 (0.67) | SLC6A12SLC6A13ACHEMCHR1KCNH2 | |
| SCHEMBL195481 | 0.80 | SLC6A12 (0.67) | SLC6A12SLC6A13ACHEALDH1A1 | |
| SCHEMBL4125164 | 0.80 | SIGMAR1 (0.77) | SLC6A12SLC6A13SIGMAR1MCHR1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5028616-A | Antiarrhythmia Agents | G. D. SEARLE & CO. (US) | 1991-07-02 | — | — | US | claimed |
| EP-0416581-A1 | Substituted N-benzylpiperidine amides | G.D. Searle & Co. (US) | 1991-03-13 | — | — | EP | claimed |
| US-5028616-A | Antiarrhythmia Agents | G. D. SEARLE & CO. (US) | 1991-07-02 | — | — | US | disclosed |