Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 2/20 | 0.61 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.56 |
| ▸ | FLT3 | P36888 | 3/20 | 0.54 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.53 |
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.50 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29415603 | 1.00 | DAO (0.61) | DAOPIN1FLT3LOXL2CA12 | |
| SCHEMBL32666155 | 0.77 | FLT3 (0.59) | FLT3PDGFRBPDGFRAHRH4 | |
| SCHEMBL2454392 | 0.77 | FLT3 (0.59) | FLT3PDGFRBPDGFRAHRH4 | |
| SCHEMBL29727931 | 0.77 | CYP2A6 (0.63) | DAOPIN1FLT3LOXL2CA12 | |
| SCHEMBL75581 | 0.77 | CYP2A6 (0.63) | DAOPIN1FLT3LOXL2CA12 | |
| SCHEMBL16767844 | 0.76 | DAO (1.00) | DAOPIN1FLT3CA12CA9 | |
| SCHEMBL8740607 | 0.74 | DAO (0.61) | DAOFLT3LOXL2RAB9AKDM4E | |
| SCHEMBL5997557 | 0.74 | LOXL2 (0.53) | DAOPIN1FLT3LOXL2CA12 | |
| SCHEMBL130537 | 0.74 | LOXL2 (0.58) | DAOPIN1FLT3LOXL2CA12 | |
| SCHEMBL11165749 | 0.74 | LOXL2 (0.53) | DAOPIN1FLT3LOXL2CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102702068-B | 3-pyrrolo-cyclohexylidene-2-dihydroindolone derivative, and application of 3-pyrrolo-cyclohexylidene-2-dihydroindolone derivative | NANJING YOKO BIOLOG PHARMACEUTICAL RES CO LTD | 2014-05-14 | — | — | CN | disclosed |
| CN-102702068-A | 3-pyrrolo-cyclohexylidene-2-dihydroindolone derivative, and application of 3-pyrrolo-cyclohexylidene-2-dihydroindolone derivative | JIANGSU SIMCERE PHARM RES CO | 2012-10-03 | — | — | CN | disclosed |
| CN-101389624-B | 3-pyrrolocyclohexylidene-2-indolinone derivative and application thereof | JIANGSU SIMCERE PHARM RES CO | 2012-10-03 | — | — | CN | disclosed |
| CN-101389624-A | 3-pyrrolocyclohexylidene-2-indolinone derivative and application thereof | JIANGSU SIMCERE PHARMACEUTICAL (CN) | 2009-03-18 | — | — | CN | disclosed |
| CN-101200446-A | 3-pyrrole ring caproic subunit-2-dihydroindolone derivatives and uses thereof | JIANGSU SIMCERE PHARMACEUTICAL (CN) | 2008-06-18 | — | — | CN | disclosed |
| CN-101195601-A | 2-dihydro indolone derivant, preparation method and application thereof | JIANGSU SIMCERE PHARMACEUTICAL (CN) | 2008-06-11 | — | — | CN | disclosed |
| CN-1250526-C | Pyrrole substituted 2-indolinone protein kinase inhibitors | SUGEN INC (US) | 2006-04-12 | — | — | CN | disclosed |
| CN-1311775-A | Pyrrole substituted 2-indolinone protein kinase inhibitors | SUGEN INC (US) | 2001-09-05 | — | — | CN | disclosed |
| EP-0428441-A2 | Keratinic fibre dyeing compostions containing oxydation dye precursors and derivatives of 4-hydroxyindole as couplers, and dyeing process using same | L'OREAL (FR) | 1991-05-22 | — | — | EP | disclosed |
| CN-1008733-B | Be used as the preparation of 2-oxyindole-1-methane amide that the 3-of anodyne and antiphlogistic replaces | PFIZER (US) | 1990-07-11 | — | — | CN | disclosed |
| CN-1007428-B | PROCESS FOR MAKING 2-OXINDOLE-1-CARBOXAMIDES AND INTERMEDIATES THEREFOR | PFIZER (US) | 1990-04-04 | — | — | CN | disclosed |
| CN-1003855-B | Process for preparing 1, 3-disubstituted 2-oxindoles | 美国辉瑞有限公司 | 1989-04-12 | — | — | CN | disclosed |
| CN-85101795-A | With 1, the two 2-oxyindoles that replace of 3-prepare pain killer and antiphlogistic | — | 1987-04-08 | — | — | CN | disclosed |
| CN-85103527-A | Preparation N, the method for the disubstituted 2-hydroxyindole of 3--1-hydroxyalkyl cooh amide | — | 1987-01-28 | — | — | CN | disclosed |
| CN-85101029-A | The method of preparation-2-oxyindole-1-methane amide and intermediate product thereof | — | 1987-01-24 | — | — | CN | disclosed |
| CN-85101028-A | Be used as the preparation of 2-oxyindole-1-methane amide that the 3-of anodyne and antiphlogistic replaces | — | 1987-01-17 | — | — | CN | disclosed |