Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.49 |
| ▸ | CASP6 | P55212 | 5/20 | 0.49 |
| ▸ | CASP3 | P42574 | 2/20 | 0.49 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.49 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.49 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 5/20 | 0.46 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | BLM | P54132 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31720854 | 0.81 | RNASEH1 (0.61) | MAOAKMT2ACASP6CASP3SENP8 | |
| SCHEMBL9382466 | 0.81 | RNASEH1 (0.61) | MAOAKMT2ACASP6CASP3SENP8 | |
| SCHEMBL12320654 | 0.80 | HPGD (0.42) | MAOAKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL14288783 | 0.78 | TTR (0.53) | MAOAKMT2ACASP6CASP3SENP8 | |
| SCHEMBL1462133 | 0.76 | HPGD (0.55) | KMT2ACASP6CASP3SENP8SENP7 | |
| SCHEMBL30642087 | 0.76 | HPGD (0.55) | KMT2ACASP6CASP3SENP8SENP7 | |
| SCHEMBL6300271 | 0.74 | KMT2A (0.49) | MAOAKMT2ACASP6CASP3SENP8 | |
| SCHEMBL14095571 | 0.74 | KMT2A (0.49) | MAOAKMT2ACASP6CASP3SENP8 | |
| Hydrochloric Acid SCHEMBL4417151 | 0.73 | CASP6 (0.47) | MAOAKMT2ACASP6CASP3SENP8 | |
| SCHEMBL2259762 | 0.71 | CES1 (0.59) | MAOACASP3GAAALDH1A1BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0408525-A2 | Use in therapy of 10-amino-5,6-dihydro-11H-dibenzo(b,e)azepine-6,11-dione and derivatives as drugs for use in the treatment of urinary incontinence | A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE S.R.L. (IT) | 1991-01-16 | — | — | EP | disclosed |