SCHEMBL9852734

SCHEMBL9852734

CN[C@H](C=O)Cc1ccc(F)cc1

nearest known ligand 0.42

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
TRPA1 O75762 2/20 0.42
TAAR1 Q96RJ0 1/20 0.41
LMNA P02545 1/20 0.40
NOS3 P29474 1/20 0.38
NOS1 P29475 1/20 0.38
NOS2 P35228 1/20 0.38
CAPN1 P07384 2/20 0.37
HPGD P15428 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
TP53 P04637 1/20 0.36
TSHR P16473 1/20 0.36
HTT P42858 1/20 0.36
MAOA P21397 1/20 0.36
MAOB P27338 1/20 0.36
ACE P12821 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13599518 0.83 CAPN1 (0.38) CAPN1HPGDTP53TSHRMAOA
SCHEMBL15203048 0.81 NR3C1 (0.36) TAAR1CAPN1
SCHEMBL8347031 0.81 LOXL2 (0.39) TRPA1TAAR1LMNANOS3NOS1
SCHEMBL9728421 0.81 SLC6A2 (0.46) TAAR1CAPN1TDP1TP53TSHR
SCHEMBL12879827 0.81 TSHR (0.41) CAPN1TDP1TP53TSHRACE
SCHEMBL24153033 0.81 CYP1A2 (0.46) CAPN1TP53TSHRACE
SCHEMBL12154596 0.81 TAAR1 (0.46) TAAR1CAPN1
SCHEMBL9630785 0.81 TAAR1 (0.46) TAAR1CAPN1
SCHEMBL4541734 0.81 TAAR1 (0.46) TAAR1CAPN1
SCHEMBL9852774 0.81 SLC6A2 (0.46) TAAR1CAPN1TDP1TP53TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0417454-A2 Reduced size LHRH analogs ABBOTT LABORATORIES (US) 1991-03-20 EP claimed
EP-3405477-B1 INHIBITORS OF TRANSGLUTAMINASES ZEDIRA GMBH (DE) 2023-06-07 EP disclosed
EP-3342779-A1 INHIBITORS OF TRANSGLUTAMINASES Zedira GmbH (DE) 2018-07-04 EP disclosed
WO-2017136708-A1 SYNTHESIS AND COMPOSITION OF RAPAFUCIN LIBRARIES THE JOHNS HOPKINS UNIVERSITY (US) 2017-08-10 WO disclosed
WO-2017044633-A1 PEPTIDOMIMETIC MACROCYCLES AS MODULATORS OF MCL-1 AILERON THERAPEUTICS, INC. (US) 2017-03-16 WO disclosed
WO-2016049359-A1 PEPTIDOMIMETIC MACROCYCLES AND USES THEREOF AILERON THERAPEUTICS, INC. (US) 2016-03-31 WO disclosed
WO-2016049355-A1 PEPTIDOMIMETIC MACROCYCLES AND FORMULATIONS THEREOF AILERON THERAPEUTICS, INC. (US) 2016-03-31 WO disclosed
WO-2013123266-A1 PEPTIDOMIMETIC MACROCYCLES AILERON THERAPEUTICS, INC. (US) 2013-08-22 WO disclosed
WO-2013123267-A1 TRIAZOLE-CROSSLINKED AND THIOETHER-CROSSLINKED PEPTIDOMIMETIC MACROCYCLES AILERON THERAPEUTICS, INC. (US) 2013-08-22 WO disclosed
WO-2013059525-A1 PEPTIDOMIMETIC MACROCYLES AILERON THERAPEUTICS, INC. (US) 2013-04-25 WO disclosed