Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 9/20 | 0.88 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.88 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.88 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.88 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.88 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.88 |
| ▸ | LMNA | P02545 | 2/20 | 0.70 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.70 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.70 |
| ▸ | ACHE | P22303 | 2/20 | 0.70 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.70 |
| ▸ | ESR1 | P03372 | 1/20 | 0.70 |
| ▸ | MAPT | P10636 | 1/20 | 0.70 |
| ▸ | BLM | P54132 | 1/20 | 0.70 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.59 |
| ▸ | TNF | P01375 | 2/20 | 0.59 |
| ▸ | USP2 | O75604 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10694108 | 0.94 | PDE4A (0.91) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL10695543 | 0.94 | PDE4A (0.91) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| Denbufylline SCHEMBL127152 | 0.94 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| Denbufylline SCHEMBL7299526 | 0.94 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL10873386 | 0.93 | PDE4A (0.77) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| Denbufylline SCHEMBL11044404 | 0.93 | PDE4A (0.97) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL7802893 | 0.92 | PDE4A (0.83) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL10872056 | 0.92 | PDE4A (0.95) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL7323464 | 0.91 | PDE4A (0.93) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL11456819 | 0.89 | PDE4A (0.77) | PDE4APDE4BPDE4CPDE4DADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0421587-A2 | Xanthine derivatives used in asthma | Beecham Group p.l.c. (GB) | 1991-04-10 | — | — | EP | claimed |
| US-4657910-A | Treatment of cerebrovascular disorders and/or disorders associated with cerebral senility | BEECHAM-WUELFING GMBH & CO. KG (DE) | 1987-04-14 | — | — | US | claimed |
| EP-0195496-A2 | Use of xanthines in the treatment of proliferative skin disease | BEECHAM GROUP PLC (GB) | 1986-09-24 | — | — | EP | claimed |
| EP-0042706-B1 | XANTHINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND A PROCESS FOR THEIR PREPARATION | BEECHAM - WUELFING GmbH & Co. KG (DE) | 1985-12-27 | — | — | EP | claimed |
| US-4372959-A | TREATMENT OF PERIPHERAL VASCULAR DISEASE | BEECHAM-WULFING GMBH & CO. KG (DE) | 1983-02-08 | — | — | US | claimed |
| EP-0042706-A2 | Xanthine derivatives, pharmaceutical compositions containing them and a process for their preparation | BEECHAM - WUELFING GmbH & Co. KG (DE) | 1981-12-30 | — | — | EP | claimed |
| EP-0421587-A2 | Xanthine derivatives used in asthma | Beecham Group p.l.c. (GB) | 1991-04-10 | — | — | EP | disclosed |
| EP-0195496-A2 | Use of xanthines in the treatment of proliferative skin disease | BEECHAM GROUP PLC (GB) | 1986-09-24 | — | — | EP | disclosed |
| EP-0173039-A2 | Use of xanthine and thioxanthine derivatives for the preparation of medicaments | BEECHAM - WUELFING GmbH & Co. KG (DE) | 1986-03-05 | — | — | EP | disclosed |
| EP-0042706-B1 | XANTHINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND A PROCESS FOR THEIR PREPARATION | BEECHAM - WUELFING GmbH & Co. KG (DE) | 1985-12-27 | — | — | EP | disclosed |
| EP-0157098-A1 | Xanthine derivatives, pharmaceuticals compositions containing them and a process for their preparation | Beecham Wuelfing GmbH & Co KG (DE) | 1985-10-09 | — | — | EP | disclosed |
| US-4372959-A | TREATMENT OF PERIPHERAL VASCULAR DISEASE | BEECHAM-WULFING GMBH & CO. KG (DE) | 1983-02-08 | — | — | US | disclosed |
| EP-0042706-A2 | Xanthine derivatives, pharmaceutical compositions containing them and a process for their preparation | BEECHAM - WUELFING GmbH & Co. KG (DE) | 1981-12-30 | — | — | EP | disclosed |