Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 12/20 | 1.00 |
| ▸ | PDE4B | Q07343 | 11/20 | 1.00 |
| ▸ | PDE4C | Q08493 | 11/20 | 1.00 |
| ▸ | PDE4D | Q08499 | 11/20 | 1.00 |
| ▸ | ADORA2A | P29274 | 6/20 | 1.00 |
| ▸ | ADORA2B | P29275 | 4/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.60 |
| ▸ | BLM | P54132 | 2/20 | 0.60 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | ESR1 | P03372 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.60 |
| ▸ | ACHE | P22303 | 1/20 | 0.60 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | CNOT7 | Q9UIV1 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Denbufylline SCHEMBL7299526 | 1.00 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| Denbufylline SCHEMBL11044404 | 0.99 | PDE4A (0.97) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL10872056 | 0.97 | PDE4A (0.95) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL7323464 | 0.96 | PDE4A (0.93) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL10694108 | 0.95 | PDE4A (0.91) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL10695543 | 0.95 | PDE4A (0.91) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL9853391 | 0.94 | PDE4A (0.88) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL10694974 | 0.92 | PDE4A (0.84) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL10694979 | 0.92 | PDE4A (0.84) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL10697104 | 0.89 | PDE4A (0.79) | PDE4APDE4BPDE4CPDE4DADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2235 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2828242-B1 | NOVEL POLYMORPHIC CRYSTAL FORMS OF 5-(2-{[6-(2,2-DIFLUORO-2-PHENYLETHOXY)HEXYL]AMINO}-1-(R)-HYDROXYETHYL)-8-HYDROXYQUINOLIN-2(1H)-ONE, HEMINAPADISYLATE AS AGONIST OF THE ß2 ADRENERGIC RECEPTOR. | ALMIRALL SA (ES) | 2017-10-04 | — | — | EP | claimed |
| US-20170049756-A1 | COMBINATIONS COMPRISING ANTIMUSCARINIC AGENTS AND PDE4 INHIBITORS | GRAS ESCARDO JORDI (ES) | 2017-02-23 | — | — | US | claimed |
| CN-104203918-B | Novel polymorphic crystal forms of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1-(r)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one, heminapadisylate as agonist of the beta2 adrenergic receptor. | 阿尔米雷尔有限公司 | 2017-01-18 | — | — | CN | claimed |
| US-9387263-B2 | RbAp48 transgenic mice for drug discovery in age-related memory decline | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2016-07-12 | — | — | US | claimed |
| US-9346759-B2 | Polymorphic crystal forms of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1-(R)-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one, heminapadisytlate as agonist of the β2 adrenergic receptor | ALMIRALL, S.A. (ES) | 2016-05-24 | — | — | US | claimed |
| US-20150306079-A1 | COMBINATIONS COMPRISING ANTIMUSCARINIC AGENTS AND PDE4 INHIBITORS | GRAS ESCARDO JORDI (ES) | 2015-10-29 | — | — | US | claimed |
| US-20150119399-A1 | BETA-CELL REPLICATION PROMOTING COMPOUNDS AND METHODS OF THEIR USE | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2015-04-30 | — | — | US | claimed |
| US-9016221-B2 | Surface topographies for non-toxic bioadhesion control | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2015-04-28 | — | — | US | claimed |
| US-20150080359-A1 | COMBINATIONS COMPRISING ANTIMUSCARINIC AGENTS AND PDE4 INHIBITORS | GRAS ESCARDO JORDI (ES) | 2015-03-19 | — | — | US | claimed |
| US-20150065471-A1 | SALTS OF 5-[(1R)-2-(AMINO)-1-HYDROXYETHYL]-8-HYDROXYQUINOLIN-2(1H)-ONE | ALMIRALL, S.A. (ES) | 2015-03-05 | — | — | US | claimed |
| US-4784999-A | Novel treatment | BEECHAM WUELFING GMBH & CO. KG (DE) | 1988-11-15 | — | — | US | claimed |
| EP-0267676-A2 | Use of 1,3-di-n-butyl-7-(2-oxypropyl) xanthine in the treatment of cerebrovascular or cerebral senility associated disorders, peripheral vascular disease and proliferative skin diseases | Beecham Wuelfing GmbH & Co KG (DE) | 1988-05-18 | — | — | EP | claimed |
| US-4657910-A | Treatment of cerebrovascular disorders and/or disorders associated with cerebral senility | BEECHAM-WUELFING GMBH & CO. KG (DE) | 1987-04-14 | — | — | US | claimed |
| EP-0005015-B1 | USE OF A XANTHINE DERIVATE IN THE MANUFACTURE OF A MEDICAMENT | BEECHAM - WUELFING GmbH & Co. KG (DE) | 1986-10-29 | — | — | EP | claimed |
| EP-0195496-A2 | Use of xanthines in the treatment of proliferative skin disease | BEECHAM GROUP PLC (GB) | 1986-09-24 | — | — | EP | claimed |
| EP-0173039-A2 | Use of xanthine and thioxanthine derivatives for the preparation of medicaments | BEECHAM - WUELFING GmbH & Co. KG (DE) | 1986-03-05 | — | — | EP | claimed |
| US-4256750-A | Pharmaceutical compositions | Wulfing, Johann A. (DE) | 1981-03-17 | — | — | US | claimed |
| US-4242345-A | VASODILATORS | Wulfing, Johann A. (DE) | 1980-12-30 | — | — | US | claimed |
| US-4225607-A | TREATMENT OF PERIPHERAL VASCULAR DISEASE | Wulfing, Johann A. (DE) | 1980-09-30 | — | — | US | claimed |
| EP-0005015-A1 | Use of a xanthine derivate in the manufacture of a medicament | BEECHAM - WUELFING GmbH & Co. KG (DE) | 1979-10-31 | — | — | EP | claimed |