Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 8/20 | 0.80 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.80 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.80 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.80 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.80 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.80 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | ESR1 | P03372 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | ACHE | P22303 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | BRD2 | P25440 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11078871 | 0.89 | PDE4A (0.66) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| Denbufylline SCHEMBL7299526 | 0.89 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| Denbufylline SCHEMBL127152 | 0.89 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| Denbufylline SCHEMBL11044404 | 0.88 | PDE4A (0.97) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL10872056 | 0.86 | PDE4A (0.95) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL7323464 | 0.85 | PDE4A (0.93) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL11072235 | 0.85 | PDE4A (0.67) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL10694108 | 0.84 | PDE4A (0.91) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL10695543 | 0.84 | PDE4A (0.91) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL11074992 | 0.84 | PDE4A (0.77) | PDE4APDE4BPDE4CPDE4DADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0421587-A2 | Xanthine derivatives used in asthma | Beecham Group p.l.c. (GB) | 1991-04-10 | — | — | EP | claimed |
| US-4657910-A | Treatment of cerebrovascular disorders and/or disorders associated with cerebral senility | BEECHAM-WUELFING GMBH & CO. KG (DE) | 1987-04-14 | — | — | US | claimed |
| EP-0195496-A2 | Use of xanthines in the treatment of proliferative skin disease | BEECHAM GROUP PLC (GB) | 1986-09-24 | — | — | EP | claimed |
| EP-0173039-A2 | Use of xanthine and thioxanthine derivatives for the preparation of medicaments | BEECHAM - WUELFING GmbH & Co. KG (DE) | 1986-03-05 | — | — | EP | claimed |
| US-4454138-A | TREATMENT OF VASCULAR DISEASES | Wuelfing, Johann A. (DE) | 1984-06-12 | — | — | US | claimed |
| EP-0018136-B1 | XANTHINE DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS | BEECHAM - WUELFING GmbH & Co. KG (DE) | 1983-11-16 | — | — | EP | claimed |
| EP-0421587-A2 | Xanthine derivatives used in asthma | Beecham Group p.l.c. (GB) | 1991-04-10 | — | — | EP | disclosed |
| EP-0195496-A2 | Use of xanthines in the treatment of proliferative skin disease | BEECHAM GROUP PLC (GB) | 1986-09-24 | — | — | EP | disclosed |
| EP-0173039-A2 | Use of xanthine and thioxanthine derivatives for the preparation of medicaments | BEECHAM - WUELFING GmbH & Co. KG (DE) | 1986-03-05 | — | — | EP | disclosed |
| US-4454138-A | TREATMENT OF VASCULAR DISEASES | Wuelfing, Johann A. (DE) | 1984-06-12 | — | — | US | disclosed |
| EP-0018136-B1 | XANTHINE DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS | BEECHAM - WUELFING GmbH & Co. KG (DE) | 1983-11-16 | — | — | EP | disclosed |
| EP-0018136-A1 | Xanthine derivatives, a process for their preparation and their use in pharmaceutical compositions | BEECHAM - WUELFING GmbH & Co. KG (DE) | 1980-10-29 | — | — | EP | disclosed |