Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 3/20 | 0.50 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.50 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9442757 | 0.75 | CHRNA7 (0.54) | CHRNA7CHRNB2CHRNA4ALDH1A1CHRM2 | |
| Hydrochloric Acid SCHEMBL9442635 | 0.74 | CHRNA7 (0.53) | CHRNA7CHRNB2CHRNA4ALDH1A1CHRM2 | |
| SCHEMBL1217690 | 0.71 | HRH3 (0.44) | CHRNA7CHRNB2CHRNA4MAPTTDP1 | |
| SCHEMBL5228523 | 0.71 | CHRNA7 (0.62) | CHRNA7CHRNB2CHRNA4KMT2A | |
| SCHEMBL6354340 | 0.70 | NPEPPS (0.44) | MAPTALDH1A1NPEPPSRIPK1HSD11B1 | |
| SCHEMBL6344810 | 0.70 | CXCR4 (0.42) | MAPTALDH1A1NPEPPSRIPK1HSD11B1 | |
| SCHEMBL19463939 | 0.70 | CHRNB2 (0.56) | CHRNA7CHRNB2CHRNA4MAPTTDP1 | |
| SCHEMBL12644364 | 0.70 | CXCR4 (0.42) | MAPTALDH1A1NPEPPSHSD11B1KDM4E | |
| SCHEMBL3182932 | 0.70 | CHRNB2 (0.56) | CHRNA7CHRNB2CHRNA4MAPTTDP1 | |
| SCHEMBL14235834 | 0.70 | CHRNB2 (0.56) | CHRNA7CHRNB2CHRNA4MAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0412798-A2 | Substituted pyridines, their preparation, formulations and use in dementia | MERCK SHARP & DOHME LTD. (GB) | 1991-02-13 | — | — | EP | disclosed |