Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.45 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.45 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.45 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RAD52 | P43351 | 1/20 | 0.42 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9853611 | 0.98 | CYP3A4 (0.45) | CYP3A4LMNACYP1A2CYP2D6CYP2C9 | |
| SCHEMBL9853585 | 0.87 | CYP3A4 (0.46) | CYP3A4LMNACYP1A2CYP2D6CYP2C9 | |
| SCHEMBL11095020 | 0.81 | ALDH1A1 (0.58) | CYP3A4SIRT2SIRT1SIRT3KDM4E | |
| SCHEMBL17678671 | 0.77 | CA12 (0.39) | CYP3A4LMNACYP1A2CYP2D6CYP2C9 | |
| SCHEMBL11275925 | 0.77 | PTGS1 (0.50) | CYP3A4CYP1A2CYP2C19GPBAR1HTT | |
| SCHEMBL29577853 | 0.76 | HTR1B (0.54) | CYP3A4CYP1A2CYP2C19KDM4EKCNA3 | |
| SCHEMBL442767 | 0.76 | HTR1B (0.54) | CYP3A4CYP1A2CYP2C19KDM4EKCNA3 | |
| SCHEMBL9853600 | 0.75 | PIN1 (0.56) | LMNACYP1A2CYP2C9GPBAR1HTT | |
| Lithium SCHEMBL6571336 | 0.74 | HTR1B (0.52) | CYP1A2CYP2C19KDM4EKCNA3HPGD | |
| Methane SCHEMBL10959030 | 0.74 | HTR1B (0.52) | CYP1A2CYP2C19KDM4EKCNA3HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4931457-A | Naphthylamino-and naphthyloxy-pyridinamine comounds useful as topical antiinflammatory agents for the treatment of skin disorders | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1990-06-05 | — | — | US | claimed |
| EP-0405426-A2 | Naphthylamino- and naphthyloxy-pyridinamines and related compounds, a process for their preparation and their use as dermatological agents | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-01-02 | — | — | EP | disclosed |
| US-4931457-A | Naphthylamino-and naphthyloxy-pyridinamine comounds useful as topical antiinflammatory agents for the treatment of skin disorders | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1990-06-05 | — | — | US | disclosed |